Document Detail


Ubiquitin-like polypeptide inhibits cAMP-induced p38 MAPK activation in Th2 cells.
MedLine Citation:
PMID:  15124858     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ubi-L, an isoform of the monoclonal nonspecific suppressor factor (MNSF), is an 8.5-kDa ubiquitin-like polypeptide. Ubi-L exhibits an antigen-nonspecific immunosuppressive function on various target cells including murine T helper type 2 (Th2) clone, D10 cells. Ubi-L specifically binds to cell surface receptors on D10 cells. In this study, we observed that Ubi-L inhibited cAMP-induced IL-5 mRNA expression in D10 cells but not in thymoma cell line EL4. In addition, Ubi-L effectively inhibited cAMP-induced p38 MAPK activation in D10 cells. Ubi-L also showed inhibitory activity on IL-5 and IL-13 production by D10 cells stimulated with phorbol ester plus dibutyryl cAMP. Furthermore, Ubi-L inhibited IL-4 production in Th2 cells derived from primary CD4+ T cells.
Authors:
Morihiko Nakamura; Yoshinori Tanigawa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Immunobiology     Volume:  208     ISSN:  0171-2985     ISO Abbreviation:  Immunobiology     Publication Date:  2004  
Date Detail:
Created Date:  2004-05-04     Completed Date:  2004-11-24     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  439-44     Citation Subset:  IM    
Affiliation:
Cooperative Medical Research Center, Shimane Medical University, School of Medicine, Izume, Japan. nkmr0515@med.shimane-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Blotting, Northern
CD4-Positive T-Lymphocytes / metabolism
Cyclic AMP / metabolism*
Interleukin-13 / metabolism
Interleukin-5 / biosynthesis,  genetics
Mice
Mice, Inbred BALB C
RNA, Messenger / metabolism
Th2 Cells / enzymology*,  metabolism
Time Factors
Ubiquitins / metabolism*
p38 Mitogen-Activated Protein Kinases / antagonists & inhibitors*
Chemical
Reg. No./Substance:
0/Interleukin-13; 0/Interleukin-5; 0/RNA, Messenger; 0/Ubiquitins; 60-92-4/Cyclic AMP; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases

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