Document Detail


Ubiquitin-dependent sorting of integral membrane proteins for degradation in lysosomes.
MedLine Citation:
PMID:  17689064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The pathways that deliver newly synthesized proteins that reside in lysosomes are well understood on comparison with our knowledge of how integral membrane proteins are sorted and delivered to the lysosome for degradation. Many membrane proteins are sorted to lysosomes following ubiquitination, which provides a sorting signal that can operate for sorting at the TGN (trans-Golgi network), at the plasma membrane or at the endosome for delivery into lumenal vesicles. Candidate multicomponent machines that can potentially move ubiquitinated integral membrane cargo proteins have been identified, but much work is still required to ascertain which of these candidates directly recognize ubiquitinated cargo and what they do with cargo after recognition. In the case of the machinery required for sorting into the lumenal vesicles of endosomes, other functions have also been determined including a link between sorting and movement of endosomes along microtubules.
Authors:
Robert C Piper; J Paul Luzio
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2007-08-03
Journal Detail:
Title:  Current opinion in cell biology     Volume:  19     ISSN:  0955-0674     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2007-12-14     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  459-65     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Membrane / physiology*
Endosomes / physiology
Humans
Lysosomes / metabolism*
Membrane Proteins / metabolism*
Protein Transport / physiology
Ubiquitin / physiology*
Grant Support
ID/Acronym/Agency:
079895//Wellcome Trust; G9310915//Medical Research Council; R01 GM058202-09/GM/NIGMS NIH HHS; R01 GM58202/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Membrane Proteins; 0/Ubiquitin
Comments/Corrections

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