| Ubiquinol-10 and ubiquinone-10 levels in umbilical cord blood of healthy foetuses and the venous blood of their mothers. | |
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MedLine Citation:
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PMID: 20815779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Despite their being good markers of oxidative stress for clinical use, little is known about ubiquinol-10 (reduced coenzyme Q10) and ubiquinone-10 (oxidized coenzyme Q10) levels in foetuses and their mothers. This study investigates oxidative stress in 10 healthy maternal venous, umbilical arterial and venous bloods after vaginal delivery by measuring ubiquinol-10 and ubiquinone-10 levels. Serum ubiquinol-10 and ubiquinone-10 levels were measured by HPLC with a highly sensitive electrochemical detector. Maternal venous ubiquinol-10 and ubiquinone-10 levels were significantly higher than umbilical arterial and venous levels (all p < 0.001). However, the ubiquinone-10/total coenzyme Q10 (CoQ10) ratio, which reflects the redox status, was significantly higher in umbilical arterial and umbilical venous blood compared to maternal venous blood (all p < 0.001). The ubiquinone-10/total CoQ10 ratio was higher in umbilical arterial than in umbilical venous blood (p < 0.01). The present study demonstrated that foetuses were under higher oxidative stress than their mothers. |
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Authors:
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Masayo Matsuzaki; Megumi Haruna; Yoko Hasumi; Kyouichi Sekine; Takashi Tanizaki; Etsuko Watanabe; Sachiyo Murashima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Free radical research Volume: 44 ISSN: 1029-2470 ISO Abbreviation: Free Radic. Res. Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-10-14 Completed Date: 2011-01-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423872 Medline TA: Free Radic Res Country: England |
Other Details:
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Languages: eng Pagination: 1338-44 Citation Subset: IM |
Affiliation:
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Department of Midwifery and Women's Health, Division of Health Sciences & Nursing, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. msumi-tky@umin.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chromatography, High Pressure Liquid Cross-Sectional Studies Female Fetal Blood / chemistry, metabolism* Fetus* Humans Mothers Pregnancy / blood* Ubiquinone / analogs & derivatives*, blood Young Adult |
| Chemical | |
Reg. No./Substance:
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1339-63-5/Ubiquinone; 56275-39-9/ubiquinol; 7704-04-3/Ubiquinone Q2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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