| UVB-induced epidermal hyperproliferation is modified by a single, topical treatment with a mitosis inhibitory epidermal pentapeptide. | |
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MedLine Citation:
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PMID: 2295825 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A single application of a water-miscible cream base containing the recently identified mitosis inhibitory epidermal pentapeptide pyroGlu-Glu-Asp-Ser-GlyOH (EPP) to hairless mouse skin is followed by a long-lasting period of reduced epidermal cell proliferation. To examine if a similar growth inhibition could be achieved in stimulated and rapidly proliferating epidermis, EPP was applied at two different concentrations, 0.005 or 0.02%, to hairless mouse skin immediately after exposure of the left flank to an erythemic dose of ultraviolet B light (UVB). This dose of UVB alone induces a sustained period of rapid epidermal cell proliferation, starting at about 18 h after the irradiation. Epidermal cell proliferation was followed from 18 to 54 h (0.005% cream) or from 18 to 30 h (0.02% cream) after the treatment by estimating the rate of G2-M cell flux (the mitotic rate) by means of Colcemid, and epidermal DNA synthesis by counting labeled cells after pulse-labeling with 3H-thymidine. The unirradiated side of the mice was used as reference. The results showed that topical treatment with a 0.02% EPP cream partially inhibited UVB-induced epidermal hyperproliferation, while the 0.005% EPP cream inhibited as well as stimulated the UVB-induced hyperproliferation. Thus, EPP is effective even in rapidly proliferating epidermal cell populations, but the outcome is obviously dose-dependent in this test system. |
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Authors:
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W M Olsen; K Elgjo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of investigative dermatology Volume: 94 ISSN: 0022-202X ISO Abbreviation: J. Invest. Dermatol. Publication Date: 1990 Jan |
Date Detail:
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Created Date: 1990-02-09 Completed Date: 1990-02-09 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0426720 Medline TA: J Invest Dermatol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 101-6 Citation Subset: IM |
Affiliation:
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Institute of Pathology, University of Oslo, Rikshospitalet, Norway. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Division / drug effects, radiation effects Epidermis / cytology* Female Growth Inhibitors / pharmacology Mice Mice, Hairless Mitosis / drug effects Oligopeptides / pharmacology* Pyrrolidonecarboxylic Acid / analogs & derivatives Time Factors Ultraviolet Rays* |
| Chemical | |
Reg. No./Substance:
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0/Growth Inhibitors; 0/Oligopeptides; 106678-69-7/epidermal pentapeptide; 98-79-3/Pyrrolidonecarboxylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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