Document Detail

"High-dose" UVA1 therapy of widespread plaque-type, nodular, and erythrodermic mycosis fungoides.
MedLine Citation:
PMID:  11260537     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: UVA1 (340 to 400 nm) was found to be effective in the treatment of early-stage mycosis fungoides (MF). OBJECTIVE: The purpose of this study was to assess the efficacy of UVA1 phototherapy for widespread plaque-type, nodular, and erythrodermic MF. METHODS: Thirteen patients (8 with stage IB, 4 with IIB, and 1 with III MF) received 100 J/cm(2) UVA1 daily until remission. Four patients also had lesions inaccessible by UVA1 that were considered control lesions. Immunocytologic studies of skin infiltrates and circulating T cells were done before and after the therapy. RESULTS: Eleven patients showed complete clinical and histologic responses. Two patients had a partial improvement. Unirradiated control lesions never improved. Serious short-term side effects were not recorded. Circulating CD4(+)/CD45RO(+) and CD4(+)/CD95(+) lymphocytes were significantly reduced by the therapy. CONCLUSION: UVA1 therapy is an effective and well-tolerated treatment for advanced MF. The therapeutic relevance of the effects on circulating lymphocytes remains to be established because lesions in nonexposed cutaneous areas did not respond.
C Zane; C Leali; P Airò; G De Panfilis; P C Pinton
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  44     ISSN:  0190-9622     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-03-22     Completed Date:  2001-06-14     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  629-33     Citation Subset:  IM    
Dermatology Department, Azienda Spedali Civili di Brescia, University of Brescia, Italy.
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MeSH Terms
Aged, 80 and over
Dermatitis, Exfoliative / blood,  etiology,  radiotherapy
Lymphocytes / physiology,  radiation effects
Middle Aged
Mycosis Fungoides / blood,  complications,  pathology,  radiotherapy*
Radiotherapy Dosage
Skin Neoplasms / blood,  complications,  pathology,  radiotherapy*
Ultraviolet Therapy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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