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UVA (UVA-1) therapy for the treatment of acute GVHD of the skin.
MedLine Citation:
PMID:  20921941     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Long-wavelength UVA (340-400 nm UVA-1) phototherapy has been reported to be effective in atopic dermatitis, localized scleroderma and T-cell-derived skin diseases. We retrospectively investigated 70 patients with acute cutaneous GVHD after allogeneic haematopoietic cell transplantation or donor lymphocyte infusion. Complete and partial responses with a median duration of 10 months were achieved in 49 (70%) and 17 (24.3%) patients, respectively. Overall, 47 (67.1%) patients were not treated with systemic steroids. Furthermore, immunosuppression could be tapered in 24 (34.3%) patients while they were receiving UVA-1 treatment. Responses were seen irrespective of age or type of conditioning. Treatment was very well tolerated. After a median follow-up of 18 (range 10-60) months, three patients developed epithelial skin neoplasia. We conclude that UVA-1 therapy is feasible, well tolerated and can be an effective treatment for acute GVHD of the skin, thereby avoiding the use of systemic steroids and/or allowing a more rapid tapering of systemic immunosuppression in a substantial number of patients. The results of this retrospective analysis warrant larger, prospective studies and the effectiveness of UVA-1 therapy should be compared with other established treatment modalities.
Authors:
M Schlaak; S Schwind; T Wetzig; J Maschke; R Treudler; N Basara; T Lange; J C Simon; D Niederwieser; H K Al-Ali
Publication Detail:
Type:  Journal Article     Date:  2010-10-04
Journal Detail:
Title:  Bone marrow transplantation     Volume:  45     ISSN:  1476-5365     ISO Abbreviation:  Bone Marrow Transplant.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8702459     Medline TA:  Bone Marrow Transplant     Country:  England    
Other Details:
Languages:  eng     Pagination:  1741-8     Citation Subset:  IM    
Affiliation:
Department for Dermatology and Venerology, University of Cologne, Cologne, Germany.
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