Document Detail


UV irradiation after immunization induces type 1 regulatory T cells that suppress Th2-type immune responses via secretion of IL-10.
MedLine Citation:
PMID:  19450899     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
It is well documented that exposure to ultraviolet (UV) radiation in sunlight before immunization suppresses systemic as well as local immune responses. We have previously shown that administrating UV irradiation 7 days after immunization also suppresses Th1- and Th2-driven antibody (Ab) via generation of antigen (Ag)-specific CD4(+) regulatory T cells. In this study, we specifically show that IL-10, which is produced by CD4(+) regulatory T cells generated in mice that received UV irradiation after immunization, mediates the suppression of Ab responses by inhibiting Th cell activation. In addition, IL-10 produced upon Ag-specific activation by UV-induced regulatory T cells also mediates bystander suppression. Furthermore, because UV irradiation after immunization effectively dampens both Th1 and Th2 immune responses, we further demonstrated that mice receiving UV irradiation after allergen sensitization had reduced Th2-driven airway inflammation and airway hyperreactivity (AHR). These results suggest that UV irradiation in pre-sensitized individuals induces Ag-specific IL-10 producing regulatory T cells representing type 1 regulatory T cells that suppress Th2 immunity and may have therapeutic potential for asthmatic patients.
Authors:
Linan Wang; Kanako Saito; Masaaki Toda; Tomohide Hori; Mie Torii; Ning Ma; Naoyuki Katayama; Hiroshi Shiku; Kagemasa Kuribayashi; Takuma Kato
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-05-17
Journal Detail:
Title:  Immunobiology     Volume:  215     ISSN:  1878-3279     ISO Abbreviation:  Immunobiology     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-01     Completed Date:  2010-05-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8002742     Medline TA:  Immunobiology     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  124-32     Citation Subset:  IM    
Affiliation:
Department of Cellular and Molecular Immunology, Mie Graduate School of Medicine, Tsu, Mie, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Down-Regulation
Female
Hypersensitivity / immunology,  prevention & control
Immunity, Active / radiation effects*
Immunization
Immunosuppression / methods*
Interleukin-10 / metabolism*
Lymphocyte Activation / radiation effects
Mice
Mice, Inbred C57BL
Ovalbumin / immunology
T-Lymphocytes, Regulatory / immunology,  radiation effects*
Th2 Cells / immunology*,  radiation effects
Ultraviolet Rays*
Chemical
Reg. No./Substance:
130068-27-8/Interleukin-10; 9006-59-1/Ovalbumin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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