Document Detail


UV-induced interaction between p38 MAPK and p53 serves as a molecular switch in determining cell fate.
MedLine Citation:
PMID:  21050851     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
p53 plays a fundamental role in the maintenance of genome integrity after DNA damage, deciding whether cells repair and live, or die. However, the rules that govern its choice are largely undiscovered. Here we show that the functional relationship between p38 and p53 is crucial in defining the cell fate after DNA damage. Upon low dose ultraviolet (UV) radiation, p38 and p53 protect the cells from apoptosis separately. Conversely, they function together to favor apoptosis upon high dose UV exposure. Taken together, a UV-induced, dose-dependent interaction between p38 and p53 acts as a switch to determine cell fate.
Authors:
Xiaowei Gong; Aihua Liu; Xiaoyan Ming; Peng Deng; Yong Jiang
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-11-02
Journal Detail:
Title:  FEBS letters     Volume:  584     ISSN:  1873-3468     ISO Abbreviation:  FEBS Lett.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-03     Completed Date:  2011-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  4711-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Affiliation:
Department of Pathophysiology and Key Laboratory of Proteomics of Guangdong Province, Southern Medical University, Guangzhou, China. gongxw@fimmu.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis / radiation effects*
Cell Line
Cell Survival / radiation effects
Dose-Response Relationship, Radiation
Gene Knockout Techniques
Humans
Mice
NIH 3T3 Cells
Phosphorylation / radiation effects
Protein Binding / radiation effects
Serine
Tumor Suppressor Protein p53 / chemistry,  deficiency,  genetics,  metabolism*
Ultraviolet Rays*
p38 Mitogen-Activated Protein Kinases / deficiency,  genetics,  metabolism*
Chemical
Reg. No./Substance:
0/Tumor Suppressor Protein p53; 56-45-1/Serine; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Akt2 regulates expression of the actin-bundling protein palladin.
Next Document:  Mutations at key pore-lining positions differentiate the water permeability of fish lens aquaporin f...