| UV-A and UV-B Penetration of Normal Human Cadaveric Fingernail Plate. | |
| | |
MedLine Citation:
|
PMID: 21173303 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: To assess the extent to which UV-A and UV-B radiation can penetrate the human fingernail plate. DESIGN: The Dermalite UV light machine (National Biological, Beachwood, Ohio) was used as the source of UV radiation. The amount of UV-A and UV-B penetrating the nail plate was measured using a radiometer and compared with a control. SETTING: Academic phototherapy clinic. Patients Ten cadaver fingernails were obtained from 1 cadaver from the National Disease Research Interchange. Because the objective was to determine transmission through normal fingernails, grossly diseased or deformed nails were not used. MAIN OUTCOME MEASURES: The percentage of UV light penetration through each fingernail was calculated by dividing the amount of radiation measured when the fingernail was in front of the light by the amount of radiation measured when there was nothing in front of the light (UV with nail divided by UV without nail). RESULTS: All 10 fingernails completely blocked the UV-B light, reading 0 mW/cm(2) on the radiometer. The mean penetration of UV-A light through the fingernails was 1.65%, ranging from 0.56% for the right fifth digit to 2.43% for the left second digit. CONCLUSIONS: The nail plate completely blocked UV-B light, and only a minimal amount of UV-A light penetrated the nails. If UV is required to directly penetrate the nail to treat nail bed psoriasis, then these data suggest that therapeutic efficacy may be compromised by the intervening nail plate. This minimal penetration of UV-A light may explain why therapies such as psoralen-UV-A (PUVA) have low efficacy for the treatment of nail psoriasis. |
| | |
Authors:
|
Dana K Stern; Alia Annette Creasey; John Quijije; Mark G Lebwohl |
Related Documents
:
|
15258643 - Evolution of acoustic communication in crickets: phylogeny of eneopterinae reveals an a... 1328063 - Vibrotactile perception threshold measurements for diagnosis of sensory neuropathy. des... 827323 - The real bladder electromyogram. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2010-12-20 |
Journal Detail:
|
Title: Archives of dermatology Volume: - ISSN: 1538-3652 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372433 Medline TA: Arch Dermatol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Mount Sinai School of Medicine, New York, New York. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Reduction of Fas/CD95 Promoter Methylation, Upregulation of Fas Protein, and Enhancement of Sensitiv...
Next Document: Adalimumab for Treatment of Moderate to Severe Chronic Plaque Psoriasis of the Hands and Feet: Effic...