| UTE-T2∗ mapping of human articular cartilage in vivo: a repeatability assessment. | |
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MedLine Citation:
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PMID: 21035556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Ultrashort echo-time enhanced T2∗ (UTE-T2∗) mapping of articular cartilage is a novel quantitative MRI technique with the potential to visualize deep cartilage characteristics better than standard T2 mapping. The feasibility and intersession repeatability of UTE-T2∗ mapping of cartilage in vivo has not previously been evaluated. METHODS: Eleven asymptomatic subjects underwent repeat UTE-T2∗ imaging on a whole-body 3T MRI scanner on three consecutive days. Full-thickness, superficial and deep regions of interest (ROIs) were evaluated in the central weight-bearing zones of the medial femoral condyle (cMFC) and tibial plateau (cMTP). Intersession precision error across subjects was evaluated by the root-mean-square average coefficients of variation (RMSA-CV) and by the median of intra-subject standard deviations (SDs) of UTE-T2∗ values in each ROI. RESULTS: UTE-T2∗ values in vivo were found to be repeatable with relative (RMSA-CV) intersession precision errors of 8%, 6%, 16% for full-thickness, superficial and deep cMFC ROIs, corresponding to absolute errors (SD) of 1.2, 1.5, 1.5 ms, respectively. In cMTP tissue, UTE-T2∗ relative repeatability was 8%, 8%, 13%, corresponding to absolute repeatability of 1.0, 1.5, 2.1 ms (full-thickness, superficial, deep). UTE-T2∗ values were higher in superficial cartilage compared to deep in both cMFC (P≪0.001) and cMTP (P=0.0004) regions. CONCLUSION: In vivo 3D UTE-T2∗ mapping at 3T is feasible and can be implemented using a standard clinical MRI scanner and knee coil. Intersession precision error of UTE-T2∗ values in full-thickness ROIs in the weight-bearing regions of asymptomatic subjects is under 1.2 ms or 8% (RMSA-CV). Significant zonal and regional variations of UTE-T2∗ were seen. |
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Authors:
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A Williams; Y Qian; C R Chu |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-10-28 |
Journal Detail:
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Title: Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society Volume: 19 ISSN: 1522-9653 ISO Abbreviation: Osteoarthr. Cartil. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-27 Completed Date: 2011-02-24 Revised Date: 2012-05-16 |
Medline Journal Info:
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Nlm Unique ID: 9305697 Medline TA: Osteoarthritis Cartilage Country: England |
Other Details:
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Languages: eng Pagination: 84-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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Cartilage Restoration Center, Department of Orthopaedic Surgery, University of Pittsburgh, Pittsburgh, PA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cartilage, Articular / pathology* Echo-Planar Imaging / methods Humans Knee Joint / pathology Magnetic Resonance Imaging / methods* Reproducibility of Results Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 AR052784/AR/NIAMS NIH HHS; R01 AR052784/AR/NIAMS NIH HHS; R01 AR052784-01A1/AR/NIAMS NIH HHS; R01 AR052784-02/AR/NIAMS NIH HHS; R01 AR052784-03/AR/NIAMS NIH HHS; R01 AR052784-03S1/AR/NIAMS NIH HHS; R01 AR052784-04/AR/NIAMS NIH HHS; R01 AR052784-05/AR/NIAMS NIH HHS; R01 CA106840/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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