Document Detail

UTE-T2∗ mapping of human articular cartilage in vivo: a repeatability assessment.
MedLine Citation:
PMID:  21035556     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Ultrashort echo-time enhanced T2∗ (UTE-T2∗) mapping of articular cartilage is a novel quantitative MRI technique with the potential to visualize deep cartilage characteristics better than standard T2 mapping. The feasibility and intersession repeatability of UTE-T2∗ mapping of cartilage in vivo has not previously been evaluated.
METHODS: Eleven asymptomatic subjects underwent repeat UTE-T2∗ imaging on a whole-body 3T MRI scanner on three consecutive days. Full-thickness, superficial and deep regions of interest (ROIs) were evaluated in the central weight-bearing zones of the medial femoral condyle (cMFC) and tibial plateau (cMTP). Intersession precision error across subjects was evaluated by the root-mean-square average coefficients of variation (RMSA-CV) and by the median of intra-subject standard deviations (SDs) of UTE-T2∗ values in each ROI.
RESULTS: UTE-T2∗ values in vivo were found to be repeatable with relative (RMSA-CV) intersession precision errors of 8%, 6%, 16% for full-thickness, superficial and deep cMFC ROIs, corresponding to absolute errors (SD) of 1.2, 1.5, 1.5 ms, respectively. In cMTP tissue, UTE-T2∗ relative repeatability was 8%, 8%, 13%, corresponding to absolute repeatability of 1.0, 1.5, 2.1 ms (full-thickness, superficial, deep). UTE-T2∗ values were higher in superficial cartilage compared to deep in both cMFC (P≪0.001) and cMTP (P=0.0004) regions.
CONCLUSION: In vivo 3D UTE-T2∗ mapping at 3T is feasible and can be implemented using a standard clinical MRI scanner and knee coil. Intersession precision error of UTE-T2∗ values in full-thickness ROIs in the weight-bearing regions of asymptomatic subjects is under 1.2 ms or 8% (RMSA-CV). Significant zonal and regional variations of UTE-T2∗ were seen.
A Williams; Y Qian; C R Chu
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-28
Journal Detail:
Title:  Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society     Volume:  19     ISSN:  1522-9653     ISO Abbreviation:  Osteoarthr. Cartil.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-27     Completed Date:  2011-02-24     Revised Date:  2014-09-11    
Medline Journal Info:
Nlm Unique ID:  9305697     Medline TA:  Osteoarthritis Cartilage     Country:  England    
Other Details:
Languages:  eng     Pagination:  84-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.
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MeSH Terms
Cartilage, Articular / pathology*
Echo-Planar Imaging / methods
Knee Joint / pathology
Magnetic Resonance Imaging / methods*
Reproducibility of Results
Young Adult
Grant Support
R01 AR052784/AR/NIAMS NIH HHS; R01 AR052784/AR/NIAMS NIH HHS; R01 AR052784-01A1/AR/NIAMS NIH HHS; R01 AR052784-02/AR/NIAMS NIH HHS; R01 AR052784-03/AR/NIAMS NIH HHS; R01 AR052784-03S1/AR/NIAMS NIH HHS; R01 AR052784-04/AR/NIAMS NIH HHS; R01 AR052784-05/AR/NIAMS NIH HHS; R01 CA106840/CA/NCI NIH HHS

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