Document Detail

The USA experience with the clonidine transdermal therapeutic system.
MedLine Citation:
PMID:  8193527     Owner:  NLM     Status:  MEDLINE    
Cardiovascular diseases are the leading causes of death in the United States, with hypertension being amongst the most prevalent of the cardiovascular risk factors. Improvement of hypertension management has, in consequence, received much attention. Extensive pre- and post-marketing experience with the transdermal formulation of clonidine marketed in the USA in the mid-1980s has now been accumulated. Transdermal clonidine is effective as monotherapy in mild-moderate hypertension, and in combination with diuretics, calcium antagonists and ACE inhibitors in more resistant cases. It controls blood pressure throughout the 24-h circadian cycle. It is effective and generally well-tolerated in adolescents, the elderly, blacks, diabetics, and subjects with chronic renal insufficiency. It has been used perioperatively and for suppression of adrenergic symptoms in subjects withdrawing from addicting substances. In comparison with oral clonidine, transdermal clonidine reduces the incidence and severity of such symptomatic side-effects as dry mouth, drowsiness, and sexual dysfunction. Minor skin reactions occur at the site of application of the transdermal patch with moderate frequency. Adherence to transdermal clonidine therapy is high, and patients commonly prefer it to oral therapy. Transdermal administration of clonidine is a useful therapeutic advance in the long-term management of hypertension.
J F Burris
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Clinical autonomic research : official journal of the Clinical Autonomic Research Society     Volume:  3     ISSN:  0959-9851     ISO Abbreviation:  Clin. Auton. Res.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-06-27     Completed Date:  1994-06-27     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9106549     Medline TA:  Clin Auton Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  391-6     Citation Subset:  IM    
Department of Medicine, Georgetown University Medical Center, Washington, DC.
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MeSH Terms
Administration, Cutaneous
Clonidine / administration & dosage*,  adverse effects,  therapeutic use
Hypertension / drug therapy*
Patient Compliance
Treatment Outcome
United States
Reg. No./Substance:

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