Document Detail

US assessment of estrogen-responsive organ growth among healthy term infants: piloting methods for assessing estrogenic activity.
MedLine Citation:
PMID:  21104239     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: A mother's circulating estrogen increases over the third trimester, producing physiological effects on her newborn that wane postnatally. Estrogenization might be prolonged in newborns exposed to exogenous estrogens, such as isoflavones in soy formula.
OBJECTIVE: We evaluated ultrasonography for monitoring growth of multiple estrogen-responsive organs in healthy infants and developed organ-growth trajectories.
MATERIALS AND METHODS: We studied 38 boys (61 visits) from birth to age 6 months and 41 girls (96 visits) from birth to age 1 year using a partly cross-sectional, partly longitudinal design. We measured uterus and ovaries in girls, testes and prostate in boys, and kidneys, breasts, thymus, and thyroid in all children. We imaged all organs from the body surface in one session of < 1 h.
RESULTS: Uterine volume decreased from birth (P < 0.0001), whereas ovarian volume increased sharply until age 2 months and then decreased (P < 0.001). Testicular volume increased with age (P < 0.0001), but prostatic volume showed minimal age trend. Breast bud diameter showed no age trend in girls but declined from birth in boys (P = 0.03).
CONCLUSION: US examination of multiple estrogen-responsive organs in infants in a single session is feasible and yields volume estimates useful for assessing potential endocrine disruptor effects on organ growth.
Ruby H N Nguyen; David M Umbach; Richard B Parad; Berrit Stroehla; Walter J Rogan; Judy A Estroff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural     Date:  2010-11-23
Journal Detail:
Title:  Pediatric radiology     Volume:  41     ISSN:  1432-1998     ISO Abbreviation:  Pediatr Radiol     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-14     Completed Date:  2011-08-17     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  0365332     Medline TA:  Pediatr Radiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  633-42     Citation Subset:  IM    
Division of Epidemiology & Community Health, University of Minnesota, Minneapolis, MN, USA.
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MeSH Terms
Child Development*
Cross-Sectional Studies
Endocrine Disruptors / pharmacology
Estrogens / pharmacology*
Infant Formula / chemistry
Infant, Newborn
Longitudinal Studies
Milk, Human
Ovary / drug effects*,  ultrasonography*
Phytoestrogens / pharmacology*
Pilot Projects
Prostate / drug effects*,  ultrasonography*
Regression Analysis
Soy Foods*
Testis / drug effects*,  ultrasonography*
Uterus / drug effects*,  ultrasonography*
Grant Support
Reg. No./Substance:
0/Endocrine Disruptors; 0/Estrogens; 0/Phytoestrogens

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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