| US FDA "Redbook II" immunotoxicity testing guidelines and research in immunotoxicity evaluations of food chemicals and new food proteins. | |
| | |
MedLine Citation:
|
PMID: 10862567 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The rapid advances in the field of immunology and an understanding of the potential adverse effects of xenobiotics on the immune system have resulted in the development of a discipline in toxicology now referred to as immunotoxicology. This discipline has evolved steadily over the last 2 decades as a result of research in the national and international communities. Various US, European, and Japanese regulatory agencies have recognized a need to promulgate testing guidelines for immunotoxicity in support of the approval process involving toxicological testing. The US Food and Drug Administration "Redbook II" guidelines and some of the research conducted in support of the concepts and testing strategies are presented here. Concerns raised with regard to these guidelines are included, as are on-going initiatives in development of experimental approaches for assessing allergic potential and/or hypersensitivity responses to new foods and food constituents. |
| | |
Authors:
|
D M Hinton |
Related Documents
:
|
14978467 - Treatment of acute mania. 8061927 - Crosslinked cnbr-activated hyaluronan-collagen matrices: effects on fibroblast contract... 17950667 - Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synth... 3560877 - Variation of lumbar spine stiffness with load. 10880677 - Methylxanthines reverse the adipsic and aphagic syndrome induced by bilateral 6-hydroxy... 22053817 - Structured expert elicitation about listeria monocytogenes cross-contamination in t... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Toxicologic pathology Volume: 28 ISSN: 0192-6233 ISO Abbreviation: Toxicol Pathol Publication Date: 2000 May-Jun |
Date Detail:
|
Created Date: 2000-10-05 Completed Date: 2000-10-05 Revised Date: 2009-07-01 |
Medline Journal Info:
|
Nlm Unique ID: 7905907 Medline TA: Toxicol Pathol Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 467-78 Citation Subset: IM |
Affiliation:
|
Biochemical and Analytical Toxicology Branch, Division of Toxicological Studies, Office of Special Research Skills, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Washington, DC, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Female Food Additives / toxicity* Guidelines as Topic* Immune System / drug effects*, pathology Immune System Diseases / chemically induced* Immunosuppressive Agents / toxicity* Mice Phosphoric Acid Esters / toxicity Pregnancy Rats Rats, Sprague-Dawley Swine, Miniature Toxicity Tests / standards* United States United States Food and Drug Administration |
| Chemical | |
Reg. No./Substance:
|
0/Food Additives; 0/Immunosuppressive Agents; 0/Phosphoric Acid Esters; 115-86-6/triphenyl phosphate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Histopathologic approaches to detect changes indicative of immunotoxicity.
Next Document: Responses of the immune system to injury.