Document Detail

UPF1: a leader at the end of chromosomes.
MedLine Citation:
PMID:  22156744     Owner:  NLM     Status:  MEDLINE    
The human helicase and ATPase up-frameshift suppressor 1 (UPF1), traditionally known as a major player in several RNA quality control mechanisms, is emerging as a crucial caretaker of the stability of the genome. Work from my laboratory has provided insight into the function of UPF1 during DNA metabolism and has revealed that this versatile enzyme sustains the proper replication of telomeres, the protective structures located at the ends of linear eukaryotic chromosomes. We have supplied direct evidence that telomere replication is not completed in cells with compromised UPF1 function, leading to the accumulation of DNA damage and telomere abnormalities. We also have isolated a number of factors that physically interact with UPF1 and might represent molecular links between UPF1 and telomeres. In this paper, I re-evaluate the functions of UPF1 in maintaining the stability of telomeres and of the genome at large and suggest a model that explains how UPF1 might be recruited and function during telomere replication.
Claus M Azzalin
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nucleus (Austin, Tex.)     Volume:  3     ISSN:  1949-1042     ISO Abbreviation:  Nucleus     Publication Date:    2012 Jan-Feb
Date Detail:
Created Date:  2012-07-27     Completed Date:  2012-12-17     Revised Date:  2014-10-10    
Medline Journal Info:
Nlm Unique ID:  101518322     Medline TA:  Nucleus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-21     Citation Subset:  IM    
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MeSH Terms
DNA / metabolism
HeLa Cells
Models, Biological
Telomere / genetics,  metabolism*
Trans-Activators / chemistry,  metabolism*
Reg. No./Substance:
0/Trans-Activators; 0/UPF1 protein, human; 9007-49-2/DNA

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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