Document Detail


UPEC hemolysin: more than just for making holes.
MedLine Citation:
PMID:  22264508     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During acute cystitis, uropathogenic Escherichia coli (UPEC) induce bladder epithelial cell exfoliation, which eliminates infected cells and promotes UPEC dissemination. Dhakal and Mulvey (2012) uncover the mechanism that induces this exfoliation and reintroduce the pore-forming toxin, hemolysin, as an effector that surprisingly targets multiple host pathways to facilitate infection.
Authors:
Sheryl S Justice; David A Hunstad
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Publication Detail:
Type:  Comment; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cell host & microbe     Volume:  11     ISSN:  1934-6069     ISO Abbreviation:  Cell Host Microbe     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-01-23     Completed Date:  2012-05-14     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  101302316     Medline TA:  Cell Host Microbe     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4-5     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Adhesion*
Escherichia coli Proteins / toxicity*
Hemolysin Proteins / toxicity*
Host-Pathogen Interactions*
Humans
Immune Evasion*
Serine Proteases / metabolism*
Signal Transduction*
Uropathogenic Escherichia coli / pathogenicity*
Grant Support
ID/Acronym/Agency:
R01 DK080752/DK/NIDDK NIH HHS; R01 DK080752-04/DK/NIDDK NIH HHS; R01 DK082546/DK/NIDDK NIH HHS; R01 DK082546-03/DK/NIDDK NIH HHS; R01-DK080752/DK/NIDDK NIH HHS; R01-DK082546/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Escherichia coli Proteins; 0/Hemolysin Proteins; 0/Hlya protein, E coli; EC 3.4.-/Serine Proteases
Comments/Corrections
Comment On:
Cell Host Microbe. 2012 Jan 19;11(1):58-69   [PMID:  22264513 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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