Document Detail

UNR facilitates the interaction of MLE with the lncRNA roX2 during Drosophila dosage compensation.
MedLine Citation:
PMID:  25158899     Owner:  NLM     Status:  In-Data-Review    
Dosage compensation is a regulatory process that balances the expression of X-chromosomal genes between males (XY) and females (XX). In Drosophila, this requires non-coding RNAs and RNA-binding proteins (RBPs) whose specific functions remain elusive. Here we show that the Drosophila RBP UNR promotes the targeting of the activating male-specific-lethal complex to the X-chromosome by facilitating the interaction of two crucial subunits: the RNA helicase MLE and the long non-coding RNA roX2.
Cristina Militti; Sylvain Maenner; Peter B Becker; Fátima Gebauer
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Publication Detail:
Type:  Journal Article     Date:  2014-08-27
Journal Detail:
Title:  Nature communications     Volume:  5     ISSN:  2041-1723     ISO Abbreviation:  Nat Commun     Publication Date:  2014  
Date Detail:
Created Date:  2014-08-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101528555     Medline TA:  Nat Commun     Country:  England    
Other Details:
Languages:  eng     Pagination:  4762     Citation Subset:  IM    
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