Document Detail

UNK cells: their role in tissue re-modelling and preeclampsia.
MedLine Citation:
PMID:  17621698     Owner:  NLM     Status:  MEDLINE    
In different species of mammal, uterine natural killer (uNK) cells are massively recruited and presented at the fetal maternal interface with a spatio-temporal pattern, and regarded as a constructive element to support reproductive development. Recent insights highlight the uNK cells activation, function and interaction with local compartments, which all contribute to the initiation of vascular structural changes. New trends of uNK cells research will benefit the diagnosis, management and test treatment strategy of preeclampsia. Furthermore, we suggest that more efforts and specific studies are needed to further explore the role of uNK cells at the unique micro-environment.
Jianhong Zhang; Zhigang Tian
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in immunopathology     Volume:  29     ISSN:  1863-2297     ISO Abbreviation:  -     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-07-11     Completed Date:  2007-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308769     Medline TA:  Semin Immunopathol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  123-33     Citation Subset:  IM    
Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, 230027 Hefei, China.
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MeSH Terms
Cytotoxicity, Immunologic
Decidua / immunology,  metabolism
Embryo Implantation
HLA Antigens / immunology,  metabolism
Killer Cells, Natural / immunology*
Lymphocyte Activation
Lymphokines / immunology*,  metabolism
Maternal-Fetal Exchange / immunology*
Pre-Eclampsia / immunology*
Uterus / immunology*
Reg. No./Substance:
0/HLA Antigens; 0/Lymphokines

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