Document Detail

A UK single-centre survey of red cell antibodies in adult patients undergoing liver transplantation.
MedLine Citation:
PMID:  23763654     Owner:  NLM     Status:  Publisher    
BACKGROUND AND OBJECTIVES: Red cell antibodies may complicate blood provision and liver transplantation outcome. The aim of this survey was to document red cell antibodies in adults undergoing liver transplantation and make recommendations for clinical practice. MATERIALS AND METHODS: We completed a 10-year retrospective review of adults undergoing liver transplant, in a single UK centre using 4- to 6-weekly red cell antibody screening. RESULTS: Seven hundred and thirty seven patients were reviewed: 58 (7·9%) had antibodies. In 50 (6·8%) patients, the antibodies were clinically significant, and the commonest were Rhesus (49·5%) and Kell (11%). 33 patients had a single antibody, and the rest had multiple antibodies (range 2-5). Two-thirds of patients (38) had antibodies at presentation; 22% of these developed additional antibodies while on the waiting list or postoperatively. CONCLUSION: Consideration should be given to the proactive use of Rh- and K-typed blood in end-stage liver disease in order to reduce alloimmunization. In addition, regular antibody screening would enable staff to identify those with atypical antibodies and plan their transfusion support.
M Mushkbar; E Watkins; H Doughty
Related Documents :
10084334 - Inhibition of eosinophil infiltration into the mouse peritoneal cavity by a traditional...
1725604 - Antigen-dependent leukotriene synthesis and histamine release from igg1 passively-sensi...
158354 - Experimental allergic uveitis: clinicopathologic features associated with varying doses...
22879954 - Biotin igm antibodies in human blood: a previously unknown factor eliciting false resul...
21140224 - An easy method to detect the kinetics of cd44 antibody and its receptors on b16 cells u...
68114 - Further observations on the specificity of antigen 5 of echinococcus granulosus.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-6-13
Journal Detail:
Title:  Vox sanguinis     Volume:  -     ISSN:  1423-0410     ISO Abbreviation:  Vox Sang.     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-6-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0413606     Medline TA:  Vox Sang     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 International Society of Blood Transfusion.
Queen Elizabeth Hospital, Birmingham, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparative genomics analysis in Prunoideae to identify biologically relevant polymorphisms.
Next Document:  Pulmonary aspiration in pediatric anesthetic practice in the UK: a prospective survey of specialist ...