Document Detail

UK audit of quantification of left-ventricular function using gated myocardial perfusion imaging.
MedLine Citation:
PMID:  23880898     Owner:  NLM     Status:  Publisher    
PURPOSE: The aim of the study was to evaluate UK-wide interinstitutional reproducibility of left-ventricular functional parameters, end-systolic volume, end-diastolic volume and ejection fraction, obtained from gated myocardial perfusion imaging (GMPI) studies using technetium-99m-labelled radiopharmaceuticals. The study was carried out by the UK Institute of Physics and Engineering in Medicine Nuclear Medicine Software Quality Group.
MATERIALS AND METHODS: Ten anonymized clinical GMPI studies, five with normal perfusion and five with perfusion defects, were made available in DICOM and proprietary formats for download and through manufacturers' representatives. Two of the studies were duplicated in order to assess intraoperator repeatability, giving a total of 12 studies. Studies were made available in 8 and 16 frames/cycle.
RESULTS: A total of 58 institutions across England, Scotland, Wales and Northern Ireland participated in this study using six different computer packages. Studies were processed at centres using their normal clinical computers and software. The overall mean±SD ejection fraction for all centres was 58.5±3%; the mean end-diastolic volume was 114±12 ml and the mean end-systolic volume was 54±6 ml. The results were affected by the number of frames per cycle and by the postprocessing computer package, but not by the reconstruction filter in the filtered back-projection.
CONCLUSION: Calculation of functional parameters from GMPI using technetium-99m-labelled radiopharmaceuticals is reliable and shows limited variability across the UK.
Sarah C Cade; David O Hall; Bob Kenny; Andy Knight; Richard S Lawson; Lefteris Livieratos; Kuldip S Nijran; Duncan White;
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-22
Journal Detail:
Title:  Nuclear medicine communications     Volume:  -     ISSN:  1473-5628     ISO Abbreviation:  Nucl Med Commun     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8201017     Medline TA:  Nucl Med Commun     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
aRoyal United Hospital Bath NHS Trust, Bath bDepartment of Medical Physics and Bioengineering, University Hospitals Bristol NHS Foundation Trust, Bristol cLink Medical, Bramshill dSunderland Royal Hospital, Sunderland eCentral Manchester University Hospitals, Manchester fGuy's and St Thomas' NHS Foundation Trust gImperial College Healthcare NHS Trust, London hBarnsley Hospital NHS Foundation Trust, Barnsley, UK.
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