| The UK Adult Twin Registry (TwinsUK). | |
| | |
MedLine Citation:
|
PMID: 17254428 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The UK Adult Twin Registry was started in 1993 and consists of approximately 10,000 monozygotic (MZ) and dizygotic (DZ) adult Caucasian twins aged 16 to 85 years from all over the United Kingdom, plus some parents and siblings. It now incorporates previous twin registries from the Institute of Psychiatry and Aberdeen University. This is a volunteer sample recruited by successive media campaigns without selecting for particular diseases or traits. All twins receive a series of detailed disease and environmental questionnaires. The majority of twins have been assessed in detail clinically at several time points for several hundred phenotypes related to common diseases or intermediate traits. The focus to date has been primarily in 5 areas--cardiovascular, metabolic, musculoskeletal, ophthalmologic diseases as well as the aging process. Over 3000 DZ twins have had a 10cM genome-wide scan performed and 5000 twins tagged for over 200 candidate genes allowing both linkage and association studies. The resource has led to many successful and innovative research projects particularly in common age-related diseases, and has led to collaborations with over 80 groups worldwide. |
| | |
Authors:
|
Tim D Spector; Frances M K Williams |
Related Documents
:
|
21664968 - Substituted 2-aminothiazoles are exceptional inhibitors of neuronal degeneration in tau... 20639778 - Inflammatory bowel disease developing in paediatric and adult age. 20020138 - Adult-onset still's disease. 23605288 - Nutrigenetics and nutrigenomics of atherosclerosis. 16382018 - Cross-sectional association of kidney function with valvular and annular calcification:... 2464898 - Plasma immunoglobulin responses and disease severity in chronic relapsing experimental ... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Twin research and human genetics : the official journal of the International Society for Twin Studies Volume: 9 ISSN: 1832-4274 ISO Abbreviation: - Publication Date: 2006 Dec |
Date Detail:
|
Created Date: 2007-01-26 Completed Date: 2007-03-14 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 101244624 Medline TA: Twin Res Hum Genet Country: Australia |
Other Details:
|
Languages: eng Pagination: 899-906 Citation Subset: IM |
Affiliation:
|
Twin Research and Genetic Epidemiology Unit, Kings College London, St Thomas' Hospital Campus, London, UK. tim.spector@kcl.ac.uk |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Aged, 80 and over Biological Specimen Banks Case-Control Studies Cohort Studies Diseases in Twins / genetics Female Great Britain Humans Longitudinal Studies Male Middle Aged Phenotype Questionnaires Registries* Twin Studies as Topic* |
| Grant Support | |
ID/Acronym/Agency:
|
//Wellcome Trust |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The Taipei Adolescent Twin/Sibling Family Study II: depression, insulin resistance, and hormonal fac...
Next Document: The Birmingham Registry for Twin and Heritability Studies (BiRTHS).