Document Detail

UHRF2, another E3 ubiquitin ligase for p53.
MedLine Citation:
PMID:  22902639     Owner:  NLM     Status:  MEDLINE    
UHRF2, ubiquitin-like with PHD and ring finger domains 2, is a nuclear E3 ubiquitin ligase, which is involved in cell cycle and epigenetic regulation. UHRF2 interacts with multiple cell cycle proteins, including cyclins (A2, B1, D1, and E1), CDK2, and pRb; moreover, UHRF2 could ubiquitinate cyclin D1 and cyclin E1. Also, UHRF2 has been shown to be implicated in epigenetic regulation by associating with DNMTs, G9a, HDAC1, H3K9me2/3 and hemi-methylated DNA. We found that UHRF2 associates with tumor suppressor protein p53, and p53 is ubiquitinated by UHRF2 in vivo and in vitro. Given that both UHRF2 and p53 are involved in cell cycle regulation, this study may suggest a novel signaling pathway on cell proliferation.
Lu Bai; Xiaohui Wang; Fangmin Jin; Yan Yang; Guanhua Qian; Changzhu Duan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Retracted Publication     Date:  2012-08-09
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  425     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-10     Completed Date:  2013-01-18     Revised Date:  2013-12-30    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  908-11     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
COS Cells
Cercopithecus aethiops
HEK293 Cells
Protein Structure, Tertiary
Tumor Suppressor Protein p53 / metabolism*
Ubiquitin-Protein Ligases / metabolism*
Reg. No./Substance:
0/Tumor Suppressor Protein p53; EC protein, human; EC Ligases
Retraction In:
Biochem Biophys Res Commun. 2013 Nov 1;440(4):803   [PMID:  24344354 ]

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