Document Detail


Tyzzer's infection: host specificity of Clostridium piliforme isolates.
MedLine Citation:
PMID:  7898029     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tyzzer's disease, a well-recognized syndrome in numerous laboratory animal species, is caused by the obligate intracellular bacterium, Clostridium piliforme. Distinct isolates of C. piliforme from various laboratory animal species have been identified based on protein and antigenic heterogeneity. The goal of this study was to examine the host specificity of three well-characterized isolates of C. piliforme. Groups of mice, rats, and hamsters were experimentally infected with isolates obtained from a naturally infected mouse (M1), a naturally infected rat (R1), and a naturally infected hamster (H2). To assess infection status, animals were monitored serologically for antibody to C. piliforme over a 12-week period. Evaluation of results indicated that the M1 isolate infected rats and mice but not hamsters, whereas the R1 and H2 isolates infected only the host species from which the isolates were originally obtained. These findings suggest that C. piliforme isolates can be categorized into two types: 1) cross-infective isolates, such as M1, which can infect more than one laboratory animal species, and 2) isolates, such as R1 and H2, which have a more limited host range within laboratory animal species. These results emphasize the need to consider the host specificity of C. piliforme isolates when investigating outbreaks of Tyzzer's disease.
Authors:
C L Franklin; S L Motzel; C L Besch-Williford; R R Hook; L K Riley
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Laboratory animal science     Volume:  44     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-04-27     Completed Date:  1995-04-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  568-72     Citation Subset:  IM    
Affiliation:
Department of Veterinary Pathology, College of Veterinary Medicine, University of Missouri, Columbia 65211.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Laboratory / microbiology*
Clostridium / isolation & purification,  pathogenicity*
Clostridium Infections / microbiology,  veterinary*
Cricetinae / microbiology
Mice / microbiology
Rats / microbiology
Rodent Diseases / microbiology*
Species Specificity
Grant Support
ID/Acronym/Agency:
RR04568/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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