| Tyrosol and Hydroxytyrosol, Two Main Components of Olive Oil, Protect N2a Cells against Amyloid-β-Induced Toxicity. Involvement of the NF-κB Signaling. | |
| | |
MedLine Citation:
|
PMID: 21605049 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Alzheimer's disease (AD) is the most common form of dementia. Recently, a number of epidemiological studies have evidence that some dietary factors such as low antioxidants and vitamins intake could increase the risk of AD. In the opposite, diets rich in unsaturated fatty acids, in polyphenols, vitamins and antioxidants were identified as preventive factors. Several studies have reported that adherence to the Mediterranean diet (MeDi) was associated with a reduction in incident of dementia. The beneficial effect of MeDi may be the result of the association of some individual and non-identified food components and high consumption of olive oil. In this study we have investigated the protective effects of two components of olive oil, tyrosol (Tyr) and hydroxytyrosol (OH-Tyr), against Aβ-induced toxicity. In cultured neuroblastoma N2a cells, we found that Aβ(25-35) (100µg/ml) treatment induced a decrease of glutathione (GSH) and the activation of the transcription factor NF-κB and cell death. Our results demonstrated that the number of cell death decreased when cells were co-treated with Aβ and Tyr or OH-Tyr. However, neither of these phenolic compounds was able to prevent the decrease of GSH induced by H(2)O(2) or Aβ. We found that the increase in the nuclear translocation of the NF-κB subunits after Aβ exposure was attenuated in the presence of Tyr or OH-Tyr. These results identified two individual food components of the MeDi as neuroprotective agent against Aβ and their potential involvement in the beneficial effect of the MeDi for the prevention of AD. |
| | |
Authors:
|
C St-Laurent-Thibault; M Arseneault; F Longpré; C Ramassamy |
Related Documents
:
|
22185839 - Cytochrome p-450 cyp2e1 knockout mice are protected against high-fat diet-induced obesi... 9565879 - Milk production of holstein heifers fed either alfalfa or corn silage diets at two rate... 15753349 - The effect of a leptin single nucleotide polymorphism on quality grade, yield grade, an... 18952729 - Growing steers grazing high versus low endophyte (neotyphodium coenophialum)-infected t... 1316349 - Diet characteristics, digesta kinetics, and dry matter intake of steers grazing eastern... 18484119 - Growth performance and carcass characteristics of feedlot cattle fed different levels o... 12177169 - Selective and independent associations of phospholipid transfer protein and hepatic lip... 7134139 - Use of dietary ammonium sulfate in control of growth rate of broiler breeder replacemen... 11208559 - Diminished satiation in rats exposed to elevated levels of endogenous or exogenous chol... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-23 |
Journal Detail:
|
Title: Current Alzheimer research Volume: - ISSN: 1875-5828 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-24 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101208441 Medline TA: Curr Alzheimer Res Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
INRS-Institut Armand Frappier, 531, boul. des Prairies, Laval, Québec, H7V 1B7, Canada. Charles.Ramassamy@iaf.inrs.ca. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Dietary patterns in Alzheimer's disease and cognitive aging.
Next Document: Metabolic Syndrome, Mild Cognitive Impairment, and Dementia.