| Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation. | |
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MedLine Citation:
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PMID: 8484124 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hematopoietically expressed product of the vav proto-oncogene, Vav, shared homology with guanine nucleotide releasing factors (GRFs) [also called guanosine diphosphate-dissociation stimulators (GDSs)] that activate Ras-related small guanosine triphosphate (GTP)-binding proteins. Human T cell lysates or Vav immunoprecipitates possessed GRF activity that increased after T cell antigen receptor (TCR)-CD3 triggering; an in vitro-translated Vav fragment that contained the putative GRF domain was also active. Vav-associated GRF stimulation after TCR-CD3 ligation paralleled its tyrosine phosphorylation; both were blocked by a protein tyrosine kinase (PTK) inhibitor. Vav also was a substrate for the p56lck PTK. Thus, Vav is a PTK-regulated GRF that may be important in TCR-CD3-initiated signal transduction through the activation of Ras. |
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Authors:
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E Gulbins; K M Coggeshall; G Baier; S Katzav; P Burn; A Altman |
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Publication Detail:
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Type: Comment; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Science (New York, N.Y.) Volume: 260 ISSN: 0036-8075 ISO Abbreviation: Science Publication Date: 1993 May |
Date Detail:
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Created Date: 1993-06-01 Completed Date: 1993-06-01 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 0404511 Medline TA: Science Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 822-5 Citation Subset: IM |
Affiliation:
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Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA 92037. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Benzoquinones Cell Cycle Proteins* Fungal Proteins / metabolism GTP-Binding Proteins / metabolism Guanosine Diphosphate / metabolism* Guanosine Triphosphate / metabolism* Humans Lactams, Macrocyclic Lymphocyte Activation Lymphocyte Specific Protein Tyrosine Kinase p56(lck) Muromonab-CD3 / pharmacology Phosphorylation Protein-Tyrosine Kinases / metabolism* Proto-Oncogene Proteins / metabolism* Proto-Oncogene Proteins c-vav Quinones / pharmacology Receptor-CD3 Complex, Antigen, T-Cell / immunology Signal Transduction T-Lymphocytes / immunology*, metabolism Tumor Cells, Cultured rap GTP-Binding Proteins |
| Grant Support | |
ID/Acronym/Agency:
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CA35299/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzoquinones; 0/Cell Cycle Proteins; 0/Fungal Proteins; 0/Lactams, Macrocyclic; 0/Muromonab-CD3; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-vav; 0/Quinones; 0/Receptor-CD3 Complex, Antigen, T-Cell; 0/VAV1 protein, human; 146-91-8/Guanosine Diphosphate; 70563-58-5/herbimycin; 86-01-1/Guanosine Triphosphate; EC 2.7.10.1/Protein-Tyrosine Kinases; EC 2.7.10.2/Lymphocyte Specific Protein Tyrosine Kinase p56(lck); EC 3.6.1.-/GTP-Binding Proteins; EC 3.6.5.2/rap GTP-Binding Proteins |
| Comments/Corrections | |
Comment On:
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Science. 1993 May 7;260(5109):767-8
[PMID:
8484117
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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