Document Detail

Tyrosine kinase-stimulated guanine nucleotide exchange activity of Vav in T cell activation.
MedLine Citation:
PMID:  8484124     Owner:  NLM     Status:  MEDLINE    
The hematopoietically expressed product of the vav proto-oncogene, Vav, shared homology with guanine nucleotide releasing factors (GRFs) [also called guanosine diphosphate-dissociation stimulators (GDSs)] that activate Ras-related small guanosine triphosphate (GTP)-binding proteins. Human T cell lysates or Vav immunoprecipitates possessed GRF activity that increased after T cell antigen receptor (TCR)-CD3 triggering; an in vitro-translated Vav fragment that contained the putative GRF domain was also active. Vav-associated GRF stimulation after TCR-CD3 ligation paralleled its tyrosine phosphorylation; both were blocked by a protein tyrosine kinase (PTK) inhibitor. Vav also was a substrate for the p56lck PTK. Thus, Vav is a PTK-regulated GRF that may be important in TCR-CD3-initiated signal transduction through the activation of Ras.
E Gulbins; K M Coggeshall; G Baier; S Katzav; P Burn; A Altman
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Publication Detail:
Type:  Comment; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  260     ISSN:  0036-8075     ISO Abbreviation:  Science     Publication Date:  1993 May 
Date Detail:
Created Date:  1993-06-01     Completed Date:  1993-06-01     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  822-5     Citation Subset:  IM    
Division of Cell Biology, La Jolla Institute for Allergy and Immunology, CA 92037.
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MeSH Terms
Cell Cycle Proteins*
Fungal Proteins / metabolism
GTP-Binding Proteins / metabolism
Guanosine Diphosphate / metabolism*
Guanosine Triphosphate / metabolism*
Lactams, Macrocyclic
Lymphocyte Activation
Lymphocyte Specific Protein Tyrosine Kinase p56(lck)
Muromonab-CD3 / pharmacology
Protein-Tyrosine Kinases / metabolism*
Proto-Oncogene Proteins / metabolism*
Proto-Oncogene Proteins c-vav
Quinones / pharmacology
Receptor-CD3 Complex, Antigen, T-Cell / immunology
Signal Transduction
T-Lymphocytes / immunology*,  metabolism
Tumor Cells, Cultured
rap GTP-Binding Proteins
Grant Support
Reg. No./Substance:
0/Benzoquinones; 0/Cell Cycle Proteins; 0/Fungal Proteins; 0/Lactams, Macrocyclic; 0/Muromonab-CD3; 0/Proto-Oncogene Proteins; 0/Proto-Oncogene Proteins c-vav; 0/Quinones; 0/Receptor-CD3 Complex, Antigen, T-Cell; 0/VAV1 protein, human; 146-91-8/Guanosine Diphosphate; 70563-58-5/herbimycin; 86-01-1/Guanosine Triphosphate; EC Kinases; EC Specific Protein Tyrosine Kinase p56(lck); EC 3.6.1.-/GTP-Binding Proteins; EC GTP-Binding Proteins
Comment On:
Science. 1993 May 7;260(5109):767-8   [PMID:  8484117 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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