Document Detail

Tyrosine-induced melanogenesis shows differences in morphologic and melanogenic preferences of melanosomes from light and dark skin types.
MedLine Citation:
PMID:  15140229     Owner:  NLM     Status:  MEDLINE    
The quality, quantity and distribution of melanosomes in epidermis play a crucial role in the determination of skin color and its sensitivity to UV radiation. Melanocyte cultures originating from individuals with light and dark skin types were grown in media with varying concentration of L-tyrosine. Melanosomal melanin content and the size of the organelles were measured after subcellular fractionation. In light-skin type cells, increased melanin production resulted in a more elliptical shape of melanosomes. In melanosomes that constitutively produce more melanin, the tyrosine-induced melanogenesis caused enlargement in all dimensions. X-ray microanalysis provided evidence that the increase in sulfur content induced by high tyrosine concentration was more prominent in the melanosomes from light skin types. A ratio between pheomelanin and eumelanin found in light-skin type melanosomes by HPLC was increased more markedly than that in melanosomes from dark skin melanocytes. These findings suggest that the melanocytes of light-skinned individuals exhibit a preference for pheomelanogenesis. Pheomelanin production is a thiol-consuming process and that might increase the risk of oxidation stress in these cells. This fact, together with the limited ability of pheomelanin to absorb UV radiation may lead to an elevated skin cancer risk among light-skinned individuals.
Frans van Nieuwpoort; Nico P M Smit; Ria Kolb; Hans van der Meulen; Henk Koerten; Stan Pavel
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  122     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-05-13     Completed Date:  2004-06-25     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1251-5     Citation Subset:  IM    
Department of Dermatology, Leiden University Medical Center, Leiden, The Netherlands.
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MeSH Terms
Cells, Cultured
Chromatography, High Pressure Liquid
Culture Media / pharmacology
Epidermis / cytology*,  metabolism*
Melanins / biosynthesis
Melanosomes / drug effects,  metabolism*
Skin Pigmentation / physiology*
Sulfur / metabolism
Tyrosine / pharmacology*
Reg. No./Substance:
0/Culture Media; 0/Melanins; 0/pheomelanin; 12627-86-0/eumelanin; 55520-40-6/Tyrosine; 7704-34-9/Sulfur

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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