Document Detail

Tyrosine hydroxylase immunoreactivity in the locus coeruleus is elevated in violent suicidal depressive patients.
MedLine Citation:
PMID:  18574609     Owner:  NLM     Status:  MEDLINE    
Our postmortem study aimed to determine the impact of suicide on the number of noradrenergic neurons of the locus coeruleus (LC) in suicidal depressive patients. Noradrenergic neurons were shown by immunostaining tyrosine hydroxylase in the LC of 22 non-elderly patients with mood disorders compared to 21 age- and sex-matched normal controls. Eleven patients were suicide victims and the other eleven died of natural causes. Seven violent suicide victims revealed an increased number of tyrosine hydroxylase immunoreactive (TH-ir) neurons compared with non-violent suicide victims and controls. No difference was found between the number of TH-ir neurons in all suicidal patients and controls and between non-suicidal patients and controls. The differences of TH-immunoreactivity could neither be attributed to medication nor to the polarity of depressive disorder (unipolar/bipolar). The numbers of TH-ir neurons in suicidal patients correlated negatively with the mean doses of antidepressants. The study suggested a presynaptic noradrenergic dysregulation in the LC related to the level of self-aggression. Traditional antidepressants may, therefore, regulate noradrenergic activity of the LC in suicide patients, however, without demonstrating the suicide-preventing effect.
Tomasz Gos; Dieter Krell; Hendrik Bielau; Ralf Brisch; Kurt Trübner; Johann Steiner; Hans-Gert Bernstein; Zbigniew Jankowski; Bernhard Bogerts
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-06-20
Journal Detail:
Title:  European archives of psychiatry and clinical neuroscience     Volume:  258     ISSN:  1433-8491     ISO Abbreviation:  Eur Arch Psychiatry Clin Neurosci     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2009-01-13     Completed Date:  2009-03-02     Revised Date:  2009-05-11    
Medline Journal Info:
Nlm Unique ID:  9103030     Medline TA:  Eur Arch Psychiatry Clin Neurosci     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  513-20     Citation Subset:  IM    
Institute of Forensic Medicine, Medical University of Gdańsk, ul. Debowa 23, 80-204 Gdańsk, Poland.
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MeSH Terms
Antidepressive Agents / therapeutic use
Depressive Disorder / drug therapy,  enzymology*,  psychology
Locus Coeruleus / cytology,  enzymology*
Middle Aged
Neurons / enzymology
Postmortem Changes
Suicide / psychology*,  statistics & numerical data
Tyrosine 3-Monooxygenase / metabolism*
Violence / psychology*
Reg. No./Substance:
0/Antidepressive Agents; EC 3-Monooxygenase

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