| Tyrosine hydroxylase polymorphism (C-824T) and hypertension: a population-based study. | |
| | |
MedLine Citation:
|
PMID: 20706199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Sympathetic nervous system (SNS) overactivity is present in a large proportion of the hypertensive population and precedes the development of established hypertension. Variations in the proximal promoter of the tyrosine hydroxylase (TH) gene have been shown to influence biochemical and physiological traits in the SNS as well as hypertension. METHODS: We investigated the relationship between a common single-nucleotide polymorphism (SNP) in the proximal TH promoter (C-824T) and blood pressure (BP) in a large general population sample, characterized by 24-h ambulatory BP (ABP) monitoring and office BP measurement. RESULTS: The study population consisted of 1,221 women and 1,182 men, ages 41-71 years, without major cardiovascular diseases. Regarding the C-824T SNP, 32.4% had the C/C genotype, 50.0% the C/T genotype, and 17.6% the T/T genotype. The T/T genotype conferred an ~45% increase in relative risk of hypertension, defined by conventional criteria, compared with the C/C genotype, and participants with the T/T genotype had significantly higher mean (95% confidence interval (CI)) systolic BP (SBP) (138 (136-140) mm Hg vs. 135 (133-136)), diastolic BP (DBP) (88 (86-89) mm Hg vs. 85 (84-86)), and heart rate (68 (67-69) beats/min vs. 66 (65-67)) than participants with the C/C genotype (P < 0.05). BP, heart rate, and prevalence of hypertension were intermediate in participants with the C/T genotype. These effects were the same in women and men and whether BP was measured in the office or by 24-h ambulatory monitoring. CONCLUSION: The C-824T SNP in the proximal TH promoter influences BP and prevalence of hypertension in the general population. |
| | |
Authors:
|
Søren J Nielsen; Jørgen Jeppesen; Christian Torp-Pedersen; Tine W Hansen; Allan Linneberg; Mogens Fenger |
Related Documents
:
|
15193169 - The contribution of risk factors to blood pressure heritability estimates in young adul... 18971529 - Genetic variations of cyp2c9 in 724 japanese individuals and their impact on the antihy... 12054649 - Polymorphism in exon 4 of the human 3 beta-hydroxysteroid dehydrogenase type i gene (hs... 7911449 - Unlike human hypertension, blood pressure in a hereditary hypertensive rat strain shows... 16508579 - Heritability of left ventricular mass in a large cohort of twins. 19949639 - Metalloproteinase-3 genotype as a predictor of cardiovascular risk in hypertensive adol... 7397959 - Mechanisms by which angiotensin ii affects the heart rate of the conscious sheep. 16253539 - Comparison of simultaneous continuous intracranial pressure (icp) signals from a codman... 10824379 - Patients' views about information technology in the treatment of hypertension. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-08-12 |
Journal Detail:
|
Title: American journal of hypertension Volume: 23 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-16 Completed Date: 2011-03-03 Revised Date: 2011-06-30 |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
|
Languages: eng Pagination: 1306-11 Citation Subset: IM |
Affiliation:
|
Department of Medicine, Copenhagen University Hospital, Glostrup, Denmark. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Blood Pressure / genetics Blood Pressure Monitoring, Ambulatory Denmark / epidemiology Female Humans Hypertension / epidemiology, genetics* Male Polymorphism, Single Nucleotide Prevalence Promoter Regions, Genetic Tyrosine 3-Monooxygenase / genetics* |
| Chemical | |
Reg. No./Substance:
|
EC 1.14.16.2/Tyrosine 3-Monooxygenase |
| Comments/Corrections | |
Comment In:
|
Am J Hypertens. 2010 Dec;23(12):1250-1
[PMID:
21079583
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Age-dependent association between sleep duration and hypertension in the adult Korean population.
Next Document: Association of prescription H1 antihistamine use with obesity: results from the National Health and ...