Document Detail

Tyrosinase protein is expressed also in some neural crest derived cells which are not melanocytes.
MedLine Citation:
PMID:  3148919     Owner:  NLM     Status:  MEDLINE    
Some neural crest cells give rise to pigment cells in early ontogenesis. We tested here whether tyrosinase--a key enzyme in melanogenesis--was present in some pigment neural crest derivatives in adult hamsters. Interestingly enough, inactive tyrosinase protein was detected, using indirect immunofluorescence, in the satellite cells of spinal ganglia and Schwann cells of sciatic and facial nerves in normal adult animals. The results of cell blotting from spinal ganglia were similar to the fluorescence findings. Thus, our results seem to support the hypothesis that Schwann cells, satellite cells of spinal ganglia, and melanocytes may be more intimately related developmentally than other neural-crest-derived cells. Moreover, since we detected tyrosinase protein in cells which normally do not produce melanosomes, it could be deduced that, during the melanocyte's differentiation from its cell precursor, the expression of tyrosinase protein might precede the point when melanosomes begin to differentiate from known cytoplasmic structures.
P Haninec; J Vachtenheim
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society     Volume:  1     ISSN:  0893-5785     ISO Abbreviation:  Pigment Cell Res.     Publication Date:  1988  
Date Detail:
Created Date:  1989-05-05     Completed Date:  1989-05-05     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8800247     Medline TA:  Pigment Cell Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  340-3     Citation Subset:  IM    
Department of Anatomy, Faculty of General Medicine, Charles University, Czechoslovakia.
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MeSH Terms
Catechol Oxidase / analysis*
Facial Nerve / enzymology*
Fluorescent Antibody Technique
Ganglia, Spinal / enzymology*
Melanocytes / enzymology
Melanoma, Experimental / enzymology
Monophenol Monooxygenase / analysis*,  immunology
Neural Crest / enzymology*
Organ Specificity
Sciatic Nerve / enzymology*
Reg. No./Substance:
EC Oxidase; EC Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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