| Tyrosinase gene family and Vogt-Koyanagi-Harada disease in Japanese patients. | |
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MedLine Citation:
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PMID: 17200659 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: The aim of the present study was to examine the genetic background of Vogt-Koyanagi-Harada (VKH) disease in a Japanese population by analyzing the tyrosinase gene family (TYR, TYRP1, and dopachrome tautomerase (DCT)). METHODS: 87 VKH patients and 122 healthy controls were genotyped using seven microsatellite markers on the candidate loci. We analyzed microsatellite (MS) polymorphisms at regions within tyrosinase gene family loci. In addition, the haplotype frequencies were also estimated and statistical analysis was performed. HLA-DRB1 genotyping was performed by the PCR-restriction fragment length polymorphism (RFLP) method. RESULTS: No significant evidence for an association was found. HLA-DRB1*0405 showed a highly significant association with VKH disease compared with the healthy controls (Pc=0.000000079), as expected. CONCLUSIONS: We concluded that there is no genetic susceptibility or increased risk attributed to the tyrosinase gene family. Our results suggest the need for further genetic study and encourage a search for novel genetic loci and predisposing genes in order to elucidate the genetic mechanisms underlying VKH disease. |
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Authors:
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Yukihiro Horie; Yuko Takemoto; Akiko Miyazaki; Kenichi Namba; Satoru Kase; Kazuhiko Yoshida; Masao Ota; Yukiko Hasumi; Hidetoshi Inoko; Nobuhisa Mizuki; Shigeaki Ohno |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-12-20 |
Journal Detail:
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Title: Molecular vision Volume: 12 ISSN: 1090-0535 ISO Abbreviation: Mol. Vis. Publication Date: 2006 |
Date Detail:
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Created Date: 2007-01-03 Completed Date: 2007-02-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9605351 Medline TA: Mol Vis Country: United States |
Other Details:
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Languages: eng Pagination: 1601-5 Citation Subset: IM |
Affiliation:
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Department of Ophthalmology and Visual Sciences, Hokkaido University Graduate School of Medicine, Sapporo, Japan. y-horie@med.hokudai.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Asian Continental Ancestry Group
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genetics* Chromosome Mapping Gene Frequency Genetic Predisposition to Disease Genotype HLA-DR Antigens / genetics Haplotypes Humans Intramolecular Oxidoreductases / genetics* Membrane Glycoproteins / genetics* Microsatellite Repeats Monophenol Monooxygenase / genetics* Multigene Family Oxidoreductases / genetics* Phenotype Polymerase Chain Reaction Polymorphism, Genetic Polymorphism, Restriction Fragment Length Uveomeningoencephalitic Syndrome / genetics* |
| Chemical | |
Reg. No./Substance:
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0/HLA-DR Antigens; 0/HLA-DRB1*0405 antigen; 0/Membrane Glycoproteins; 128338-86-3/HLA-DRB1 antigen; EC 1.-/Oxidoreductases; EC 1.14.18.-/TYRP1 protein, human; EC 1.14.18.1/Monophenol Monooxygenase; EC 5.3.-/Intramolecular Oxidoreductases; EC 5.3.3.12/dopachrome isomerase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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