Document Detail


Tyrosinase Inhibitors from the Wood of Artocarpus heterophyllus.
MedLine Citation:
PMID:  23113717     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
From the methanolic-soluble extract of the wood of Artocarpus heterophyllus, four new flavones, artocarmins A-D (1-4), and three new chalcones, artocarmitins A-C (5-7), have been isolated together with 13 known compounds. Their structures were determined on the basis of the spectroscopic data. Compounds 1-4, 6, 7, 9-16, and 20 displayed significant tyrosinase inhibitory activity. The most active compound, morachalcone A (12) (IC(50), 0.013 μM), was 3000 times more active as a tyrosinase inhibitor than a positive control, kojic acid (IC(50), 44.6 μM).
Authors:
Nhan Trung Nguyen; Mai Ha Khoa Nguyen; Hai Xuan Nguyen; Ngan Kim Nguyen Bui; Mai Thanh Thi Nguyen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-31
Journal Detail:
Title:  Journal of natural products     Volume:  -     ISSN:  1520-6025     ISO Abbreviation:  J. Nat. Prod.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-11-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7906882     Medline TA:  J Nat Prod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Faculty of Chemistry, University of Science, Vietnam National University-HoChiMinh City , 227 Nguyen Van Cu Street, District 5, HoChiMinh City, Vietnam.
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