Document Detail


Typology of Na+ transport abnormalities in erythrocytes from essential hypertensive patients. A first step towards the diagnosis and specific treatment of different forms of primary hypertension.
MedLine Citation:
PMID:  2176809     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over the last 5 years, several authors have measured apparent affinities and maximal translocation rates of the different erythrocyte Na+ transport systems in essential hypertensive patients. These kinetic studies have clearly shown that no unique red cell Na+ transport defect characterizes the whole population of essential hypertensive patients. Conversely, several complex patterns of erythrocyte Na+ transport abnormalities may be present in different subsets of essential hypertensive patients. These kinetic studies are now providing a more profound biochemical insight into the molecular heterogeneity of primary hypertension. In particular, they may permit the diagnosis and specific treatment of different forms of primary hypertension in the next decade.
Authors:
R Garay
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy     Volume:  4 Suppl 2     ISSN:  0920-3206     ISO Abbreviation:  Cardiovasc Drugs Ther     Publication Date:  1990 Mar 
Date Detail:
Created Date:  1991-02-22     Completed Date:  1991-02-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8712220     Medline TA:  Cardiovasc Drugs Ther     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  373-8     Citation Subset:  IM    
Affiliation:
INSERM U7/CNRS UA 318, Hôpital Necker, Paris, France.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Transport, Active
Erythrocyte Membrane / metabolism*
Humans
Hypertension / drug therapy,  metabolism*
Rats
Rats, Inbred SHR
Sodium / metabolism*
Sodium Channels
Chemical
Reg. No./Substance:
0/Sodium Channels; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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