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MedLine Citation:
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PMID: 22156762 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The host restricts dissemination of invasive enteric pathogens, such as non-typhoidal Salmonella serovars, by mounting acute inflammatory responses characterized by the recruitment of neutrophils. However, some enteric pathogens, such as Salmonella enterica serovar Typhi (S. typhi), can bypass these defenses and cause an invasive bloodstream infection known as typhoid fever. Recent studies on virulence mechanisms of S. typhi suggest that tight regulation of virulence gene expression during the transition from the intestinal lumen into the intestinal mucosa enables this pathogen to evade detection by the innate immune system, thereby penetrating defenses that prevent bacterial dissemination. This example illustrates how the outcome of host pathogen interaction at the intestinal mucosal interface can alter the clinical presentation and dictate the disease outcome. |
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Authors:
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Tamding Wangdi; Sebastian E Winter; Andreas J Bäumler |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-01 |
Journal Detail:
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Title: Gut microbes Volume: 3 ISSN: 1949-0984 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2011-12-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101495343 Medline TA: Gut Microbes Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Medical Microbiology and Immunology; School of Medicine; University of California at Davis; Davis, CA USA. |
Export Citation:
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Descriptor/Qualifier:
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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