| Typhlitis: a treatable complication of acute leukemia therapy. | |
| | |
MedLine Citation:
|
PMID: 6933028 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Heretofore, pseudomembranous enterocolitis, or more specifically typhlitis, occurring as a complication of the cytotoxic chemotherapy of acute leukemia has nearly always resulted in a fatal outcome. Recent surgical literature states that if cecitis is found as a consequence of therapy for leukemia, the surgeon should refrain from operating because standard procedures, including hemicolectomy, have not improved survival. This paper reports two patients with acute typhlitis resulting from induction therapy of acute leukemia with cytosine arabinoside and hydroxydaunorubicin. Both patients underwent subtotal colectomy, while their marrows were aplastic from therapy, and survived their surgery. Both are living and well in maintained remission, 1 year from surgery. We review the pathogenesis of this disorder and discuss its clinical, x-ray, and laboratory features. Close oncologic/surgical teamwork is stressed as the patient is followed closely into the time frame when the decision is made whether to operate. Factors contributing to this decision are discussed. Preoperative recommendations are made in order to bring the patient into a state of physiologic stability. The operative procedure is described along with the postoperative complications encountered. We strongly recommend that laparotomy be considered in selected patients with typhlitis occurring as a complication of treated leukemia. |
| | |
Authors:
|
J W Lea; D R Masys; S R Shackford |
Related Documents
:
|
7104638 - Acute acalculous cholecystitis following trauma. 6691168 - Incidence of common bile duct stones in patients with acute and chronic cholecystitis. 8847028 - Primary carcinoma of the gallbladder--review of 143 cases. 707468 - Vagotogenic cholecystitis. 10710148 - Subarachnoid drainage of an established or chronic pseudomeningocele. 9549268 - Extravesical detrusorrhaphy for vesicoureteral reflux in children. |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Cancer clinical trials Volume: 3 ISSN: 0190-1206 ISO Abbreviation: Cancer Clin Trials Publication Date: 1980 |
Date Detail:
|
Created Date: 1981-01-29 Completed Date: 1981-01-29 Revised Date: 2007-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 7905482 Medline TA: Cancer Clin Trials Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 355-62 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Aged Antineoplastic Agents / adverse effects*, therapeutic use Child Child, Preschool Colectomy / methods Enterocolitis, Pseudomembranous / etiology*, pathology, surgery Humans Infant Leukemia, Myeloid, Acute / drug therapy Male Middle Aged |
| Chemical | |
Reg. No./Substance:
|
0/Antineoplastic Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: High-dose VP 16-213 (NSC 141540) for the treatment of patients with previously treated acute leukemi...
Next Document: An unusual case of primary osteosarcoma of the talus.