| Type I and type III procollagen propeptides in amniotic fluid of normal pregnancies and in a case of mild osteogenesis imperfecta. | |
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MedLine Citation:
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PMID: 9792997 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The propeptides derived from type I and III procollagens, PICP, PINP and PIIINP, indicate the synthesis of the corresponding collagens. Their circulating concentrations reflect the growth velocity in infants and children METHODS: We measured these propeptides in 145 samples of amniotic fluid of normal pregnancy. In addition, we have analysed an amniotic fluid and serum sample from a mother with osteogenesis imperfecta, and later the infant's serum sample was also collected for procollagen propeptide analysis. RESULTS: High concentrations of propeptides, 100-1000 times higher than those in adult serum, were found in early second trimester, decreasing significantly towards term, reflecting the decreased foetal growth rate. Interestingly, the amino-terminal propeptide of type I procollagen, PINP, decreased more that the corresponding carboxy-terminal propeptide, PICP, although both are in principle derived from the same protein. At both stages of pregnancy, the discrepant ratio of PICP to PINP indicated a molar excess of PINP. Abnormally low concentrations of PICP and PINP with normal PIIINP concentrations measured in amniotic fluid and in the serum indicated decreased synthesis of type I procollagen in a foetus/infant with mild osteogenesis imperfecta. CONCLUSIONS: Our data show a decrease in collagen synthesis with the stage of pregnancy and lower values of type I procollagen propeptides in a case of OI. |
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Authors:
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S Kauppila; A Tekay; L Risteli; M Koivisto; J Risteli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of clinical investigation Volume: 28 ISSN: 0014-2972 ISO Abbreviation: Eur. J. Clin. Invest. Publication Date: 1998 Oct |
Date Detail:
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Created Date: 1998-11-17 Completed Date: 1998-11-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0245331 Medline TA: Eur J Clin Invest Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 831-7 Citation Subset: IM |
Affiliation:
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University of Oulu, Oulu, Finland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / chemistry* Chromatography, Gel Female Humans Infant, Newborn Osteogenesis Imperfecta / metabolism* Peptide Fragments / analysis Pregnancy Pregnancy Complications / metabolism* Procollagen / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Peptide Fragments; 0/Procollagen; 0/procollagen Type III-N-terminal peptide; 0/procollagen type I carboxy terminal peptide |
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