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Type I toxin-antitoxin systems in Bacillus subtilis.
MedLine Citation:
PMID:  23059907     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Type I toxin-antitoxin (TA) systems are widespread in bacteria and consist of a toxin-encoding mRNA and a partially overlapping antisense RNA that blocks expression of the toxin, either at the level of translation or by mRNA degradation. Four type I toxin families have so far been proposed in B. subtilis based on sequence similarity: TxpA/BsrG, BsrH/BsrE, YonT and YhzE and two (TxpA and BsrG) have been studied in some detail. Here we review what is known about these confirmed and putative toxin-antitoxin families in B. subtilis, their regulatory mechanisms, their potential roles and how they may link to the physiology of the cell.
Authors:
Sylvain Durand; Natalie Jahn; Ciarán Condon; Sabine Brantl
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-11
Journal Detail:
Title:  RNA biology     Volume:  9     ISSN:  1555-8584     ISO Abbreviation:  RNA Biol     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101235328     Medline TA:  RNA Biol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
CNRS UPR 9073 (affiliated with Univ. Paris Diderot, Sorbonne Paris Cité); Institut de Biologie Physico-Chimique; Paris, France.
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