Document Detail


Type-specific antibodies to herpes simplex virus type 2 (HSV-2) glycoprotein G in pregnant women, infants exposed to maternal HSV-2 infection at delivery, and infants with neonatal herpes.
MedLine Citation:
PMID:  2826604     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We used a murine monoclonal antibody to herpes simplex virus (HSV) type 2 (HSV-2) glycoprotein G (gG) to develop an enzyme immunoassay that detected HSV-2 type-specific antibodies in human sera. Antibodies to HSV-2 gG were detected in 98 (96%) of 102 sera from pregnant women with culture-proved HSV-2 infection. Sixty-five percent of the women had serological evidence of past HSV-2 infection by the Rawls index, based on titers of neutralizing antibody to HSV type 1 and HSV-2. Thirty (88%) of 34 infants exposed to maternal HSV infection at delivery had antibodies to HSV-2 gG and remained well. One infant exposed to primary maternal HSV-2 infection lacked antibodies to HSV-2 gG and developed neonatal HSV-2 infection. The mean +/- SD optical density by HSV-2 gG enzyme-linked immunosorbent assay for sera obtained from 17 infants within one week after onset of neonatal HSV-2 infection was 0.25 +/- 0.12, compared with 1.15 +/- 0.34 in cord blood sera from exposed infants who did not develop symptoms (P less than .0001 by t test).
Authors:
W M Sullender; L L Yasukawa; M Schwartz; L Pereira; P A Hensleigh; C G Prober; A M Arvin
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  157     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-02-03     Completed Date:  1988-02-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  164-71     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Stanford University School of Medicine, California 94305.
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MeSH Terms
Descriptor/Qualifier:
Antibodies, Viral / analysis*
Enzyme-Linked Immunosorbent Assay
Female
Herpes Genitalis / immunology*
Humans
Immunoelectrophoresis
Infant, Newborn / immunology*
Neutralization Tests
Postpartum Period / immunology
Pregnancy
Pregnancy Complications, Infectious / immunology*
Radioimmunoassay
Simplexvirus / classification,  immunology*
Viral Envelope Proteins / immunology*
Grant Support
ID/Acronym/Agency:
AI-23592/AI/NIAID NIH HHS; HD-16080/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Viral Envelope Proteins; 0/glycoprotein G, herpes simplex virus type 2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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