| Type-specific antibodies to herpes simplex virus type 2 (HSV-2) glycoprotein G in pregnant women, infants exposed to maternal HSV-2 infection at delivery, and infants with neonatal herpes. | |
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MedLine Citation:
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PMID: 2826604 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We used a murine monoclonal antibody to herpes simplex virus (HSV) type 2 (HSV-2) glycoprotein G (gG) to develop an enzyme immunoassay that detected HSV-2 type-specific antibodies in human sera. Antibodies to HSV-2 gG were detected in 98 (96%) of 102 sera from pregnant women with culture-proved HSV-2 infection. Sixty-five percent of the women had serological evidence of past HSV-2 infection by the Rawls index, based on titers of neutralizing antibody to HSV type 1 and HSV-2. Thirty (88%) of 34 infants exposed to maternal HSV infection at delivery had antibodies to HSV-2 gG and remained well. One infant exposed to primary maternal HSV-2 infection lacked antibodies to HSV-2 gG and developed neonatal HSV-2 infection. The mean +/- SD optical density by HSV-2 gG enzyme-linked immunosorbent assay for sera obtained from 17 infants within one week after onset of neonatal HSV-2 infection was 0.25 +/- 0.12, compared with 1.15 +/- 0.34 in cord blood sera from exposed infants who did not develop symptoms (P less than .0001 by t test). |
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Authors:
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W M Sullender; L L Yasukawa; M Schwartz; L Pereira; P A Hensleigh; C G Prober; A M Arvin |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 157 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1988 Jan |
Date Detail:
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Created Date: 1988-02-03 Completed Date: 1988-02-03 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 164-71 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Stanford University School of Medicine, California 94305. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Antibodies, Viral
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analysis* Enzyme-Linked Immunosorbent Assay Female Herpes Genitalis / immunology* Humans Immunoelectrophoresis Infant, Newborn / immunology* Neutralization Tests Postpartum Period / immunology Pregnancy Pregnancy Complications, Infectious / immunology* Radioimmunoassay Simplexvirus / classification, immunology* Viral Envelope Proteins / immunology* |
| Grant Support | |
ID/Acronym/Agency:
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AI-23592/AI/NIAID NIH HHS; HD-16080/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Viral Envelope Proteins; 0/glycoprotein G, herpes simplex virus type 2 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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