| Type-A response regulators are required for proper root apical meristem function through the post-transcriptional regulation of PIN auxin efflux carriers. | |
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MedLine Citation:
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PMID: 21645147 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The phytohormones cytokinin and auxin regulate a diverse array of plant processes, often acting together to modulate growth and development. While much has been learned regarding how each of these hormones act individually, we are just beginning to understand how these signals interact to achieve an integrated response. Previous studies indicate that exogenous cytokinin has an effect on the transcription of several PIN efflux carriers. Here, we show that disruption of the type-A Arabidopsis Response Regulators (ARRs), which are negative regulators of cytokinin signalling, alters the levels of PIN proteins and results in increased sensitivity to NPA, an inhibitor of polar auxin transport. Disruption of eight of the ten type-A ARRs affects root development by altering the size of the apical meristem. Furthermore, we show that the effect of cytokinin on PIN abundance occurs primarily at the post-transcriptional level. Alterations of PIN levels in the type-A ARRs mutants result in changes in the distribution of auxin in root tips as measured by a DR5::GFP reporter, and an altered pattern of cell division and differentiation in the stem cell niche in the root apical meristem. Together, these data indicate that cytokinin, acting through the type-A ARRs, alters the level of several PIN efflux carriers, and thus regulates the distribution of auxin within the root tip. |
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Authors:
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Wenjing Zhang; Jennifer P C To; Chia-Yi Cheng; G Eric Schaller; Joseph J Kieber |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-6-6 |
Journal Detail:
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Title: The Plant journal : for cell and molecular biology Volume: - ISSN: 1365-313X ISO Abbreviation: - Publication Date: 2011 Jun |
Date Detail:
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Created Date: 2011-6-7 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9207397 Medline TA: Plant J Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 Blackwell Publishing Ltd and the Society for Experimental Biology. |
Affiliation:
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University of North Carolina, Biology Department, CB#3280, Chapel Hill, NC, 27599 Dartmouth College, Department of Biological Sciences, Hanover, NH, 03755. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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