Document Detail


Type of postmenopausal hormone use and risk of breast cancer: 12-year follow-up from the Nurses' Health Study.
MedLine Citation:
PMID:  1525324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We prospectively examined the use of hormone replacement therapy in relation to breast cancer incidence in a cohort of women 30 to 55 years of age in 1976. During 12 years of follow-up (480,665 person-years) among postmenopausal women, 1,050 incident cases of breast cancer were documented. Overall, past users of replacement estrogen were not at increased risk. After adjustment for established risk factors, type of menopause, age at menopause, and current age, the rate ratio (RR) was 0.91, 95 percent confidence interval (CI) = 0.78-1.07. The risk of breast cancer was elevated significantly among current users (RR = 1.33, CI = 1.12-1.57); after adjusting for age, we observed no evidence of increasing risk with increasing duration of use among current users (P trend = 0.41), or among past users (P trend = 0.46). Women currently using unopposed estrogen (RR = 1.42, CI = 1.19-1.70), estrogen and progesterone (RR = 1.54, CI = 0.99-2.39), or progesterone alone (RR = 2.52, CI = 0.66-9.63), were all at increased risk of breast cancer compared with never users. These data suggest that long-term past use of estrogen replacement therapy is not related to risk, that current estrogen use increases risk of breast cancer to a modest degree, and that the addition of progesterone does not remove the increased risk observed with current use of unopposed estrogen.
Authors:
G A Colditz; M J Stampfer; W C Willett; D J Hunter; J E Manson; C H Hennekens; B A Rosner; F E Speizer
Related Documents :
8775774 - Estrogen therapy in the management of problems associated with urogenital ageing: a sim...
8498394 - Value of a simple measure of estrogen status for improving the diagnosis of coronary ar...
18488874 - Ht update: spotlight on estradiol/norethindrone acetate combination therapy.
6837504 - Obesity, estrogen production, and tumor estrogen receptors in women with carcinoma of t...
16895744 - Ultrasonographic and doppler velocimetric evaluation of the levator ani muscle in preme...
23821244 - Seventeen year risk of all-cause and cause-specific mortality associated with c-reactiv...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Cancer causes & control : CCC     Volume:  3     ISSN:  0957-5243     ISO Abbreviation:  Cancer Causes Control     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-10-22     Completed Date:  1992-10-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9100846     Medline TA:  Cancer Causes Control     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  433-9     Citation Subset:  IM    
Affiliation:
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115-5899.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Breast Neoplasms / chemically induced*,  epidemiology
Contraceptives, Oral
Estrogen Replacement Therapy / adverse effects*
Estrogens / adverse effects*
Female
Follow-Up Studies
Humans
Middle Aged
Progestins / adverse effects*
Prospective Studies
Risk Factors
United States
Grant Support
ID/Acronym/Agency:
CA40356/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Contraceptives, Oral; 0/Estrogens; 0/Progestins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Multiple myeloma among Danish women: employment history and workplace exposures.
Next Document:  A case-control study of stomach cancer and its relation to diet, cigarettes, and alcohol consumption...