Document Detail

Type A monoamine oxidase regulates life and death of neurons in neurodegeneration and neuroprotection.
MedLine Citation:
PMID:  21971004     Owner:  NLM     Status:  In-Data-Review    
In Parkinson's disease, type B monoamine oxidase (MAO-B) is proposed to play an important role in the pathogenesis through production of reactive oxygen species and neurotoxins from protoxicants, such as 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. In addition, inhibitors of MAO-B protect neurons in the cellular and animal models of Parkinson's and Alzheimer's diseases. However, the role of type A MAO (MAO-A) in neuronal death and neuroprotection by MAO-B inhibitors has been scarcely elucidated. This chapter presents our recent results on the involvement of MAO-A in the activation of mitochondrial death signal pathway and in the induction of prosurvival genes to prevent cell death with MAO-B inhibitors. The roles of MAO-A in the regulation of neuronal survival and death are discussed in concern to find a novel strategy to protect neurons in age-associated neurodegenerative disorders and depression.
Makoto Naoi; Wakako Maruyama; Keiko Inaba-Hasegawa; Yukihiro Akao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International review of neurobiology     Volume:  100     ISSN:  0074-7742     ISO Abbreviation:  Int. Rev. Neurobiol.     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374740     Medline TA:  Int Rev Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-106     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Inc. All rights reserved.
Department of Neurosciences, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan.
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