| Type I interferon production by nucleic acid-stimulated dendritic cells. | |
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MedLine Citation:
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PMID: 18508640 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Dendritic cells (DC) detect nucleic acid adjuvants through the Toll-like receptor (TLR) or cytosolic sensors. Nucleic acid adjuvants activate DC to produce a variety of soluble factors including proinflammatory cytokines or type I interferons (IFNs). Type I IFN, especially IFN-alpha, induction is a characteristic function of nucleic acid adjuvants and critical for antiviral host defense. Notably, nucleic acids derived from the host as well as from the pathogens can function as immune adjuvants and contributes to the manifestations of autoimmune diseases through the type I IFN induction. Therefore, clarifying the molecular mechanisms for type I IFN induction by nucleic acids should contribute to the development of treatment not only for viral infection but also for autoimmune diseases. |
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Authors:
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Tsuneyasu Kaisho |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-05-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 13 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2008 |
Date Detail:
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Created Date: 2008-05-29 Completed Date: 2008-09-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 6034-42 Citation Subset: IM |
Affiliation:
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Laboratory for Host Defense, RIKEN Research Center for Allergy and Immunology, Suehiro-cho 1-7-22, Tsurumi-ku, Yokohama city, Kanagawa 230-0045, Japan. tkaisho@rcai.riken.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Autoimmunity Cytosol / immunology, physiology DNA / pharmacology Dendritic Cells / drug effects, immunology, physiology* Humans Interferon Type I / biosynthesis*, immunology RNA / pharmacology Toll-Like Receptors / immunology, physiology* Tretinoin / pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I; 0/Toll-Like Receptors; 302-79-4/Tretinoin; 63231-63-0/RNA; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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