Document Detail

Type I focal cortical dysplasia: surgical outcome is related to histopathology.
MedLine Citation:
PMID:  20659869     Owner:  NLM     Status:  MEDLINE    
Pre-surgical and post-surgical data were examined and compared from 215 consecutive patients undergoing surgery for intractable epilepsy. Patients were selected on the basis of a proven histopathological diagnosis of type I focal cortical dysplasia (FCD I), alone or associated with other lesions. The patients were divided into five sub-groups: i) 66 with isolated FCD I, ii) 76 with FCD I and hippocampal sclerosis, iii) 49 with FCD I and tumours, iv) 16 with FCD I and other malformations of cortical development and v) eight with FCD I and anoxic-ischaemic or inflammatory diseases. The duration of epilepsy was greatest in patients with FCD I associated with hippocampal sclerosis, and those with isolated FCD I showed the highest seizure frequency at the time of surgery. Hippocampal sclerosis and tumours were the most frequent pathological lesions associated with FCD I in temporal lobe epilepsy. Febrile seizures significantly correlated with the presence of hippocampal sclerosis and FCD I. Isolated FCD I was observed in 31% of the patients, characterized by frequent seizures, negative magnetic resonance imaging, and frequent frontal or multilobar involvement. In comparison to patients with FCD I associated with hippocampal sclerosis, MCD or tumours, the patients with isolated FCD I had a worse post-surgical outcome (46% in class I). Our findings indicate that there is a high incidence of FCD I associated with other apparently distinct pathologies, particularly those affecting the temporal lobe, and highlight the need for a comprehensive clinicopathological approach for the classification of FCD I.
Laura Tassi; Rita Garbelli; Nadia Colombo; Manuela Bramerio; Giorgio Lo Russo; Francesco Deleo; Gloria Milesi; Roberto Spreafico
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-27
Journal Detail:
Title:  Epileptic disorders : international epilepsy journal with videotape     Volume:  12     ISSN:  1294-9361     ISO Abbreviation:  Epileptic Disord     Publication Date:  2010 Sep 
Date Detail:
Created Date:  2010-09-08     Completed Date:  2010-10-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100891853     Medline TA:  Epileptic Disord     Country:  France    
Other Details:
Languages:  eng     Pagination:  181-91     Citation Subset:  IM    
Division of Epilepsy Clinic and Experimental Neurophysiology, C. Besta Neurological Institute IRCCS Foundation, Milan, Italy.
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MeSH Terms
Age of Onset
Brain / pathology
Cerebral Cortex / anatomy & histology,  pathology
Child, Preschool
Epilepsy / pathology,  surgery
Magnetic Resonance Imaging / methods
Malformations of Cortical Development / classification,  pathology*,  surgery*
Neurons / pathology
Reference Values
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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