| Type I focal cortical dysplasia: surgical outcome is related to histopathology. | |
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MedLine Citation:
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PMID: 20659869 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Pre-surgical and post-surgical data were examined and compared from 215 consecutive patients undergoing surgery for intractable epilepsy. Patients were selected on the basis of a proven histopathological diagnosis of type I focal cortical dysplasia (FCD I), alone or associated with other lesions. The patients were divided into five sub-groups: i) 66 with isolated FCD I, ii) 76 with FCD I and hippocampal sclerosis, iii) 49 with FCD I and tumours, iv) 16 with FCD I and other malformations of cortical development and v) eight with FCD I and anoxic-ischaemic or inflammatory diseases. The duration of epilepsy was greatest in patients with FCD I associated with hippocampal sclerosis, and those with isolated FCD I showed the highest seizure frequency at the time of surgery. Hippocampal sclerosis and tumours were the most frequent pathological lesions associated with FCD I in temporal lobe epilepsy. Febrile seizures significantly correlated with the presence of hippocampal sclerosis and FCD I. Isolated FCD I was observed in 31% of the patients, characterized by frequent seizures, negative magnetic resonance imaging, and frequent frontal or multilobar involvement. In comparison to patients with FCD I associated with hippocampal sclerosis, MCD or tumours, the patients with isolated FCD I had a worse post-surgical outcome (46% in class I). Our findings indicate that there is a high incidence of FCD I associated with other apparently distinct pathologies, particularly those affecting the temporal lobe, and highlight the need for a comprehensive clinicopathological approach for the classification of FCD I. |
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Authors:
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Laura Tassi; Rita Garbelli; Nadia Colombo; Manuela Bramerio; Giorgio Lo Russo; Francesco Deleo; Gloria Milesi; Roberto Spreafico |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-07-27 |
Journal Detail:
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Title: Epileptic disorders : international epilepsy journal with videotape Volume: 12 ISSN: 1294-9361 ISO Abbreviation: Epileptic Disord Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-08 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100891853 Medline TA: Epileptic Disord Country: France |
Other Details:
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Languages: eng Pagination: 181-91 Citation Subset: IM |
Affiliation:
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Division of Epilepsy Clinic and Experimental Neurophysiology, C. Besta Neurological Institute IRCCS Foundation, Milan, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Age of Onset Brain / pathology Cerebral Cortex / anatomy & histology, pathology Child Child, Preschool Electroencephalography Epilepsy / pathology, surgery Humans Magnetic Resonance Imaging / methods Malformations of Cortical Development / classification, pathology*, surgery* Neurons / pathology Reference Values Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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