Document Detail


Type I cryoglobulinemia in multiple myeloma: a rare entity. Analysis of clinical and biological characteristics of 7 cases and review of the literature.
MedLine Citation:
PMID:  22385269     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Abstract The type I cryoglobulins (CGs) account for 10-15% of all cryoglobulin cases and are found in patients with hematological disorders. We here describe the largest series of seven type I CG cases associated with multiple myeloma (MM) and provide a detailed review of the literature associated with this disorder with the aim of improving the future diagnosis and therapeutic management of this rare disease. Six of the cases in our series were men aged from 28-69, and most of the subject patients had an IgG monoclonal component and stage I indolent MM that manifested as cryoglobulin-related symptoms. The patients were all karyotypically normal. The clinical manifestations in this group were: skin lesions (5 cases, 71.4%), rheumatologic failure (4 cases, 57.1%), neurological abnormalities (2 cases, 28.6%), mixed cutaneous/rheumatologic/renal defects (1 case,14.3%) and one case in which the cryoglobulin was asymptomatic. Two patients experienced acute renal failure but underwent a full recovery following treatment for MM. We conclude from our analysis that treatment approaches for severe type I CG should involve plasmapheresis at the onset to achieve a rapid control of the CG-related symptoms and that specific MM treatments should be introduced also at an early stage to avoid CG relapse. In this context, bortezomib and lenalidomide are potentially the most effective therapeutic agents.
Authors:
Judith Payet; Joël Livartowski; Niloufar Kavian; Olivia Chandesris; Nicolas Dupin; Nadège Wallet; Alexandre Karras; Carine Salliot; Felipe Suarez; Hervé Avet-Loiseau; Marie Alexandra Alyanakian; Chadi Al Nawakil; Sophie Park; Jérome Tamburini; Christian Roux; Didier Bouscary; Laetitia Sparsa
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-3-2
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  -     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-3-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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