Document Detail


Type V Collagen Genotype and Exercise-Related Phenotype Relationships: A Novel Hypothesis.
MedLine Citation:
PMID:  21697718     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We have shown that a variant within COL5A1, which encodes a subunit of type V collagen, is associated with injury and performance phenotypes. Although seemingly unrelated, these phenotypes are directly or indirectly associated with the mechanical properties of musculoskeletal soft tissue. We therefore hypothesize that variants in the COL5A1 gene alters fibril architecture and structure, and thereby mechanical properties.
Authors:
Malcolm Collins; Michael Posthumus
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-18
Journal Detail:
Title:  Exercise and sport sciences reviews     Volume:  -     ISSN:  1538-3008     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375434     Medline TA:  Exerc Sport Sci Rev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
1UCT/MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa, 2The South African Medical Research Council, Cape Town, South Africa, 3International Olympic Committee (IOC) Research Centre, University of Cape Town, Cape Town, South Africa.
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