Document Detail

Type III apparatus of Pseudomonas aeruginosa as a tool to diagnose pulmonary infection in cystic fibrosis patients.
MedLine Citation:
PMID:  22779684     Owner:  NLM     Status:  In-Data-Review    
Pseudomonas aeruginosa is associated with increased mortality in cystic fibrosis (CF) patients, and expresses type III secretion system proteins (TTSP), which is a common mechanism used by gram-negative pathogens for delivery of anti-host factors. Our aim was to investigate whether or not these antigens (TTSP) would be recognized by CF sera, by Western blot reaction. We have showed herein that all patients (n = 11) not chronically infected by P. aeruginosa had their first serum positive for TTSP (ExoS, ExoT, PopB, and/or PopD). All chronic patients had a strong positive serology to TTSP, although relatively weak reactions to TTSP were observed for some individuals in the negative control group. Therefore, TTSP that were early produced in P. aeruginosa infected CF patients, induced a detectable antibody response in those patients and were easily detected by Western-blot reaction.
Aline C Cruz; Bianca C Neves; Laurinda Y S Higa; Tânia Folescu; Elizabeth A Marques; Lucimar G Milagres
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Publication Detail:
Type:  Journal Article     Date:  2012-02-11
Journal Detail:
Title:  APMIS : acta pathologica, microbiologica, et immunologica Scandinavica     Volume:  120     ISSN:  1600-0463     ISO Abbreviation:  APMIS     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803400     Medline TA:  APMIS     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  622-7     Citation Subset:  IM    
Copyright Information:
© 2012 The Authors APMIS © 2012 APMIS.
Department of Microbiology, Immunology and Parasitology, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil.
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