Document Detail


Type of Desmin Expression in Cardiomyocytes -a Good Marker of Heart Failure Development in Idiopathic Dilated Cardiomyopathy.
MedLine Citation:
PMID:  22292457     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Aim:  The aim of the present study was to determine whether remodelling of the desmin (DES) cytoskeleton affects myocardial function and whether it could be a useful marker of disease progression in patients with idiopathic dilated cardiomyopathy (IDCM). Material and methods:  Endomyocardial biopsy was performed in 195 IDCM patients and five to six specimens were collected from the left ventricle. DES expression was evaluated using tissue immunostaining and western blotting. The study population was assigned to four groups according to DES expression type: I, normal DES staining at Z-lines giving a regular pattern of cross-striation (n=57); IIA, increased DES staining with a regular pattern of cross-striation (n=40); IIB, increased DES staining with an irregular pattern of cross-striation and/or the presence of aggregates (n=56); and III, decreased/lack of DES staining (n=42). Fibrosis, cardiomyocyte hypertrophy and ultrastructure were assessed for the four types of DES expression. Results:  The pathological types of DES expression (IIB or III) were associated with pathological changes in mitochondria and the contractile apparatus. Cardiomyocyte diameter and level of fibrosis were both significantly affected. DES expression type correlated with NYHA class, left ventricular end diastolic diameter, left ventricular ejection fraction and the level of N-terminal pro-brain natriuretic protein. Conclusion:  The type of immunohistochemical DES expression correlated with the level of myocardial injury at the cellular and organ levels. This correlation was similar to that observed between DES expression and the well-established biochemical, echocardiographic and clinical parameters of heart failure (HF). DES expression type could be used as an important diagnostic feature of HF development.
Authors:
Agnieszka Pawlak; Robert J Gil; Tomasz Kulawik; Maciej Pronicki; Agnieszka Karkucińska-Więckowska; Tamara Szymańska-Dębińska; Katarzyna Gil; Nikolaj Lagwinski; Elżbieta Czarnowska
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-31
Journal Detail:
Title:  Journal of internal medicine     Volume:  -     ISSN:  1365-2796     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-2-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8904841     Medline TA:  J Intern Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 The Association for the Publication of the Journal of Internal Medicine.
Affiliation:
Department of Invasive Cardiology, Central Clinical Hospital of Ministry of Internal Affairs and Administration, Warsaw, Poland Department of Surgical Research and Transplantology, Mossakowski Medical Research Centre, Academy of Science, Warsaw, Poland Department of Pathology, The Children's Memorial Health Institute, Warsaw, Poland Department of Pathology, Community Medical Centers, Fresno, CA, USA.
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