Document Detail

Type-D personality and cortisol in survivors of acute coronary syndrome.
MedLine Citation:
PMID:  18799427     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To test the hypothesis that Type-D personality is associated with elevated cortisol levels in patients 4 months after an acute coronary syndrome (ACS). METHODS: Salivary cortisol profiles were measured at home in 70 coronary heart disease patients (Mean age = 60.90 years, SD = 10.7, 17% female) 4 months after hospitalization for ACS. Eight saliva samples were taken over the course of 1 day. RESULTS: Thirty eight percent of the ACS patients were defined as Type-D. Cortisol profiles showed a typical diurnal pattern, with low levels in the evening, high levels early in the day. Type-D was not related to the cortisol awakening response, but cortisol output the day was higher in Type-D (mean = 4443.3, SD = 2334.1 nmol/l) than non Type-D patients (mean = 3252.0, SD = 1810.2 nmol/l) after adjustment for age, gender, hypertension, Global Registry of Acute Coronary Events risk score, recurrence of cardiac symptoms, previous myocardial infarction, body mass index and concurrent depressed mood (p = .044). Type-D personality accounted for 6% over the variance in cortisol output over the day, after covariates had been taken into account. CONCLUSION: Type-D personality may be associated with prolonged disruption of the hypothalamic-pituitary-adrenal axis function in survivors of acute cardiac events and may contribute to biological responses influencing future cardiac morbidity.
Gerard J Molloy; Linda Perkins-Porras; Philip C Strike; Andrew Steptoe
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Publication Detail:
Type:  Journal Article     Date:  2008-09-16
Journal Detail:
Title:  Psychosomatic medicine     Volume:  70     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-16     Completed Date:  2009-02-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  863-8     Citation Subset:  IM    
Department of Epidemiology and Public Health, University College London, London, UK.
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MeSH Terms
Acute Coronary Syndrome / blood*,  psychology*
Angina, Unstable / blood,  psychology
Circadian Rhythm / physiology
Depressive Disorder / blood,  psychology
Follow-Up Studies
Hydrocortisone / blood*
Middle Aged
Myocardial Infarction / blood,  psychology
Personality Inventory / statistics & numerical data
Phobic Disorders / blood*,  psychology*
Regression Analysis
Risk Factors
Saliva / chemistry
Social Isolation*
Reg. No./Substance:

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