| Type C botulism in turkeys: determination of the median toxic dose. | |
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MedLine Citation:
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PMID: 8011788 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The median toxic dose (TD50) of type C botulinum in turkeys was determined using an up-and-down method for toxicologic testing. Birds were dosed intravenously with 10, 20, or 40 mouse lethal dose per kilogram body weight (MLD/kg) of type C botulism toxin and observed for 5 days. Administration of toxin resulted in acute death, posterior paresis, or no effect, depending upon the dose. The TD50 causing posterior paresis was calculated as 25.75 MLD/kg (confidence interval = 17.08-38.82 MLD/kg). Posterior paresis was identified as the principal sign associated with sublethal botulism toxicosis in turkeys. The resultant posterior paresis was similar to the clinical syndrome observed in an unsolved field investigation. |
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Authors:
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J S Jeffrey; F D Galey; C U Meteyer; H Kinde; M Rezvani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc Volume: 6 ISSN: 1040-6387 ISO Abbreviation: J. Vet. Diagn. Invest. Publication Date: 1994 Jan |
Date Detail:
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Created Date: 1994-07-26 Completed Date: 1994-07-26 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9011490 Medline TA: J Vet Diagn Invest Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 93-5 Citation Subset: IM |
Affiliation:
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California Veterinary Diagnostic Laboratory Service, University of California-Davis, Fresno 93725. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aging Animals Body Weight Botulinum Toxins / toxicity* Botulism / microbiology, veterinary* Death Dose-Response Relationship, Drug Mice Poultry Diseases* Turkeys |
| Chemical | |
Reg. No./Substance:
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0/Botulinum Toxins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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