| Type 2 innate lymphoid cells-new members of the "type 2 franchise" that mediate allergic airway inflammation. | |
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MedLine Citation:
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PMID: 22539283 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Type 2 innate lymphoid cells (ILC2s) are members of an ILCfamily, which contains NKcells and Rorγt(+) ILCs, the latter including lymphoid tissue inducer (LTi) cells and ILCs producing IL-17 and IL-22. ILC2s are dedicated to the production of IL-5 and IL-13 and, as such, ILC2s provide an early and important source of type 2 cytokines critical for helminth expulsion in the gut. Several studies have also demonstrated a role for ILC2s in airway inflammation. In this issue of the European Journal of Immunology, Klein Wolterink et al. [Eur. J. Immunol. 2012. 42: 1106-1116] show that ILC2s are instrumental in several models of experimental asthma where they significantly contribute to production of IL-5 and IL-13, key cytokines in airway inflammation. This study sheds light over the relative contribution of ILC2s versus T helper type 2 cells (Th2) in type 2 mediated allergen-specific inflammation in the airways as discussed in this commentary. |
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Authors:
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Jenny Mjösberg; Hergen Spits |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: European journal of immunology Volume: 42 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2012 May |
Date Detail:
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Created Date: 2012-04-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
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Languages: eng Pagination: 1093-6 Citation Subset: IM |
Copyright Information:
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© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
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Tytgat Institute of Intestinal and Liver Research, Academic Medical Center, Amsterdam, The Netherlands. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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