| Type 2 diabetes mellitus and prognosis in early stage breast cancer women. | |
| | |
MedLine Citation:
|
PMID: 22083554 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
It has been suggested that type 2 diabetes mellitus may affect breast cancer prognosis, possibly due to increased diabetes-related comorbidity, or direct effects of insulin resistance and/or hyperinsulinemia. The aim of this study was to determine the impact of diabetes on disease-free survival (DFS) following mastectomy for breast cancer patients. The cases included in this retrospective study were selected from breast cancer women who had undergone mastectomy and completed adjuvant chemotherapy from 1998 to 2010. Patients were classified into two groups: diabetic and non-diabetic. Patients' age, sex, menopausal status, body mass index (BMI), histopathological features, tumor size, lymph node involvement, hormone receptor and HER2-neu status, and treatment types were recorded. There were 483 breast cancer patients included in the study. Postmenopausal patients' rate (53.7% vs. 36.8%, P = 0.016) and mean BMI levels were statistically higher (32.2 vs. 27.9, P = 0.007) in diabetic patients. There was no statistical difference for histological subgroup, grade, ER and PR positivity, HER2-neu overexpression rate, and tumor size between the diabetic and non-diabetic group. Lymph node involvements were statistically higher in diabetic patients compared with non-diabetic patients (P = 0.013). Median disease-free survival is 81 months (95% CI, 61.6-100.4) in non-diabetic patients and 36 months (95% CI, 13.6-58.4) in diabetic patients (P < 0.001). The odds ratio of recurrence was significantly increased in those with HER2-neu overexpression and lymph node involvement and decreased with PR-positive tumors. Our results suggest that diabetes is an independent prognostic factor for breast cancer. |
| | |
Authors:
|
Muhammet Ali Kaplan; Zafer Pekkolay; Mehmet Kucukoner; Ali Inal; Zuhat Urakci; Hamza Ertugrul; Recai Akdogan; Ugur Firat; Ismail Yildiz; Abdurrahman Isikdogan |
Related Documents
:
|
15521814 - Neuroprotection by alpha-lipoic acid in streptozotocin-induced diabetes. 2533444 - Reduction in blood and urine glucose levels in streptozotocin and alloxan diabetes by p... 12789654 - Increase in adenosine a1 receptor gene expression in the liver of streptozotocin-induce... 18371934 - Effect of experimental diabetes on craniofacial growth in rats. 20967384 - Diabetes induces compositional, structural and functional alterations on rat skeletal s... 12230294 - Prevalence of mild impairment in renal function in a random sample of elders from a bie... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-15 |
Journal Detail:
|
Title: Medical oncology (Northwood, London, England) Volume: - ISSN: 1559-131X ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9435512 Medline TA: Med Oncol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Medical Oncology, Dicle University, 21280, Diyarbakir, Turkey, drmalikaplan@hotmail.com. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Computer-Based Route-Definition System for Peripheral Bronchoscopy.
Next Document: Differential Prognostic Effect of Revascularization According to a Simple Comorbidity Index in High-...