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Type 2 diabetes mellitus, insulin use, and risk of bladder cancer in a large cohort study.
MedLine Citation:
PMID:  23024033     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Type 2 diabetes mellitus (T2DM) is associated with increased bladder cancer incidence in some, but not all, studies. Many studies had limited statistical power and few examined risk by insulin- use, duration of diabetes, or cancer stage. We examined the association between T2DM and bladder cancer incidence in the Cancer Prevention Study II Nutrition Cohort, a large prospective study with information on insulin use and duration of diabetes. Diabetes and insulin use were ascertained from a questionnaire at study enrollment in 1992 or 1993 and updated in 1997 and every two years thereafter. During follow-up through 2007, 1,852 cases of incident bladder cancer were identified among 172,791 participants. Multivariable adjusted relative risks (RRs) and 95% confidence intervals (CIs) were estimated using extended Cox regression modeling. There were no associations of T2DM with risk of bladder cancer overall (RR = 1.01, 95% CI: 0.87-1.17), non-invasive disease (RR = 0.93, 95% CI: 0.76-1.14), or invasive disease (RR = 1.13, 95% CI: 0.91-1.40). Compared to participants without T2DM, risk of invasive bladder cancer was higher among participants who had had T2DM for < 15 years (RR = 1.63, 95% CI: 1.09-2.43) and among those using insulin (RR = 1.64, 95% CI: 1.18-2.27). These results do not support an association of T2DM with overall bladder cancer incidence, but do suggest positive associations of long-term T2DM and insulin-use, or other factors correlated with severe diabetes, with invasive bladder cancer incidence. © 2012 Wiley-Liss, Inc.
Authors:
Christina C Newton; Susan M Gapstur; Peter T Campbell; Eric J Jacobs
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-10-1
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  -     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 UICC.
Affiliation:
All authors are affiliated with the Epidemiology Research Program, American Cancer Society, Atlanta, GA. christina.newton@cancer.org.
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