| Type 2 diabetes mellitus, insulin use, and risk of bladder cancer in a large cohort study. | |
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MedLine Citation:
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PMID: 23024033 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Type 2 diabetes mellitus (T2DM) is associated with increased bladder cancer incidence in some, but not all, studies. Many studies had limited statistical power and few examined risk by insulin- use, duration of diabetes, or cancer stage. We examined the association between T2DM and bladder cancer incidence in the Cancer Prevention Study II Nutrition Cohort, a large prospective study with information on insulin use and duration of diabetes. Diabetes and insulin use were ascertained from a questionnaire at study enrollment in 1992 or 1993 and updated in 1997 and every two years thereafter. During follow-up through 2007, 1,852 cases of incident bladder cancer were identified among 172,791 participants. Multivariable adjusted relative risks (RRs) and 95% confidence intervals (CIs) were estimated using extended Cox regression modeling. There were no associations of T2DM with risk of bladder cancer overall (RR = 1.01, 95% CI: 0.87-1.17), non-invasive disease (RR = 0.93, 95% CI: 0.76-1.14), or invasive disease (RR = 1.13, 95% CI: 0.91-1.40). Compared to participants without T2DM, risk of invasive bladder cancer was higher among participants who had had T2DM for < 15 years (RR = 1.63, 95% CI: 1.09-2.43) and among those using insulin (RR = 1.64, 95% CI: 1.18-2.27). These results do not support an association of T2DM with overall bladder cancer incidence, but do suggest positive associations of long-term T2DM and insulin-use, or other factors correlated with severe diabetes, with invasive bladder cancer incidence. © 2012 Wiley-Liss, Inc. |
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Authors:
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Christina C Newton; Susan M Gapstur; Peter T Campbell; Eric J Jacobs |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-10-1 |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: - ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2012 Oct |
Date Detail:
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Created Date: 2012-10-1 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 UICC. |
Affiliation:
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All authors are affiliated with the Epidemiology Research Program, American Cancer Society, Atlanta, GA. christina.newton@cancer.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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